Teratogens Flashcards

1
Q

ACE inhibitors

A

Renal damage

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2
Q

Alkylating agents

A

Absence of digits

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3
Q

Aminoglycosides

A

CN VIII toxicity

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4
Q

Carbamazepine

A
Neural tube defects
Craniofacial defects
Fingernail hypoplasia
Developmental delay
IUGR
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5
Q

DES

A

Vaginal clear cell adenocarcinoma

Congenital mullerian anomalies

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6
Q

Folate antagonists

A

Neural tube defects

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7
Q

Lithium

A

Ebstein anomaly

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8
Q

Methimazole

A

Aplasia cutis congenita

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9
Q

Phenytoin

A

Fetal hydantoin syndrome

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10
Q

What is Fetal hydantoin syndrome

A
Microcephaly
Dysmorphic craniofacial features
Hyplastic nails and distal phalanges
Cardiac defects
IUGR
Intellectual disability
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11
Q

Tetracyclines

A

Discoloured teeth

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12
Q

Thalidomide

A

Limb defects

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13
Q

Valproate

A

Inhibition of maternal folate absorption

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14
Q

Warfarin

A

Bone deformities

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15
Q

Alcohol

A

FAS

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16
Q

Cocaine

A

Placental abruption

17
Q

Smoking

A
LBW
Preterm labor
Placental problems
IUGR
ADHD
18
Q

Iodine

A

Goiter

Hypothyroidism

19
Q

Maternal diabetes

A

Caudal regression syndrome
Congenital heart defects
Neural tube defects

20
Q

Vitamin A excess

A

Spontaneous abortions

Birth defects

21
Q

X-rays

A

Microencephaly

Intellectual disability