Oncogenes Flashcards

1
Q

BCR-ABL

A

CML
AML
Tyrosine kinase

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2
Q

Bcl-2

A

Follicular and undifferentiated lymphoma

Anti-apoptotic

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3
Q

BRAF

A

Melanoma

Ser/Thr kinase

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4
Q

c-kit

A

GIST

Cytokine receptor

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5
Q

c-myc

A

Burkitt lymphoma

Transcription factor

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6
Q

Her2/neu

A

Breast
Ovarian
Gastric carcinoma
Tyrosine kinase

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7
Q

L-myc

A

Lung tumor

Transcription factor

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8
Q

N-myc

A

Neuroblastoma

Transcription factor

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9
Q

Ras

A

Colon cancer
Lung cancer
Pancreatic cancer
GTPase

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10
Q

Ret

A

MEN 2A, 2B
Papillary thyroid carcinoma
Tyrosine kinase

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