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CC 2 LEC FINALS > TDM PART 2 > Flashcards

TDM PART 2 Flashcards

1
Q

Acts by decreasing motor cortex activity

A

ETHOSUXIMIDE

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2
Q

ETHOSUXIMIDE

A

“Zarontin”

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3
Q

ETHOSUXIMIDE
Half life:

A

○ 60 hours (adults)
○ 30 hours (children)

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4
Q

FELBAMATE
Indications: severe epilepsies

A

● Half life: 14-22 hours adults
● Therapeutic range: 30-60 ug/mL
● Nearly complete absorption in the GIT
● Peak level 1-4 hours after oral dose
◆ Complete absorption
● Elimination renal and hepatic metabolism
● Higher clearance in children with liver dysfunction

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5
Q

FELBAMATE
___ of Felbamate is bound to proteins,

A

30%

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6
Q

AEDs which reduces its half life:

A

○ Phenobarbital
○ Primidone
○ Phenytoin
○ Carbamazepine

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7
Q

indications: partial and generalized seizure

A

LAMOTRIGINE

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8
Q

LAMOTRIGINE

A

Half life:15-30 hours
● Therapeutic range: 2.5-15 ug/mL

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9
Q

____ is an inhibitor of Lamotrigine

A

🔊 Valproic acid

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10
Q

Lamotrigine
___% is bound to protein

A

🔊 55

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11
Q

Such as for those children with mix seizure disorders
and for those children with lennox-gastaut syndrome

A

FELBAMATE

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12
Q

Indication: treatment of partial and generalized seizures

A

LEVETIRACETAM

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13
Q

LEVETIRACETAM

A

● Half Life: 6-8 hours 🔊 Shorter half life for this drug is not bound to proteins
➔ All portion of this drug is considered to be active
or potent portion
● Therapeutic range: 8-26 ug/mL

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14
Q

Indications monotherapy or together with other AEDs
(anti-epileptic drugs) for complex partial seizures

A

GABAPENTIN

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15
Q

GABAPENTIN

A

Half life: 5-9 hours
● Therapeutic range: 12-20 ug/mL
● Excessive increased level
○ Toxic adverse effects
● Decreased trough concentration
○ May lead to seizures
Treatment of liver disease and partial onset seizure in
patients with acute intermittent porphyria
● 90% bioavailability
Elimination: renal filtration

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16
Q

Indications monotherapy of practical seizures and in tonic
clonic seizure

A

OXCARBAZEPINE

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17
Q

OXCARBAZEPINE

A

Half life: 8-10 hours
● Therapeutic range: 12-35 ug/mL
● Metabolite: Licarbazepine
Metabolism keto reduction followed by glucuronide
conjugation
Peak level: 8 hours after administration

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18
Q

OXCARBAZEPINE
___ is bound to proteins

A

40%

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19
Q

TIAGABINE

A

Half life: 4-13 hours
● Therapeutic range: 20-100 ng/mL
● Peak level: 30 minutes - 1 hour after administration
● Metabolism MFO system
● Side effects
○ Symptoms of confusion
○ Stuttering
○ Mild sedation
○ Paresthesia - tingling sensation in the
extremities such as in the fingers, hand, toes,
and feet

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20
Q

Indication for treatment of partial seizures

A

TIAGABINE

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21
Q

TIAGABINE
____ is bound to proteins

A

🔊 96%

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22
Q

TOPIRAMATE

A

Indications treatment of partial and generalized seizure
● Half -life: 20-30 hours
● Peak level: within 1-4 hours after administration 🔊 15% is bound to proteins 🔊 Major route is through the kidney
➔ Some part enters the liver for metabolism
● Elimination: majority through renal filtration
● Dose titration: to balance therapeutic effects
● Side effects in the CNS

23
Q

● Side effects in the CNS
○ Change of taste with some food
○ “Pins and needles” sensation

A

TOPIRAMATE

24
Q

ZONISAMIDE

A

Indications: treatment of partial and generalized seizures
● Half-life:
○ 50-70 hours (monotherapy)
🔊 Taken alone = Prolonged Half-life
○ 25-35 hours (together with other AEDs)
🔊 Faster elimination
● Therapeutic Range: 10-38 ug/mL
● Peak Level: 4-7 hours

25
Q

Primidone is the prodrug of ____

A

Phenobarbital

26
Q

CARBAMAZEPINE
OTHER TERM

A

Tegretol

27
Q

CARBAMAZEPINE
OTHER TERM

A

Tegretol

28
Q

ANTIDEPRESSANTS

A

Lithium
Tricyclic antidepressants
Clozapine
Olanzapine
Fluoxetine

29
Q

ANTICONVULSANTS

A

Phenobarbital
Phenytoin
Primidone
Lamotrigine
Levetiracetam
Tiagabine
Topiramate
Carbamazepine
Oxcarbazepine
Valproic acid
Ethosuximide
Felbamate
Zonisamide
Gabapentin

30
Q

Treatment and
prophylaxis of
manic phase of
manic
depression

A

LITHIUM

31
Q

Treatment of
depression,
insomnia, extreme
apathy
and loss of libido

A

TRICYCLIC
ANTIDEPRESSANT
(TCAD)

32
Q

Treatment of
refractory
schizophrenia

A

CLOZAPINE

33
Q

Treatment of
schizophrenia,
acute manic
episodes, and
the recurrence of
bipolar
disorders

A

OLANZAPINE

34
Q

Treatment of OCDs

A

FLUOXETIN

35
Q

Blocks the reuptake of adrenergic and
dopaminergic neurotransmitters

A

TRICYCLIC ANTIDEPRESSANTS (TCAD)

36
Q

TRICYCLIC ANTIDEPRESSANTS (TCAD)
METABOLITE

A

Metabolite: Desipramine
● Therapeutic range: 100-300

37
Q

Indication: treatment of refractory schizophrenia

A

CLOZAPINE

37
Q

Indication: treatment of refractory schizophrenia

A

CLOZAPINE

38
Q

Blocks serotonin reuptake in the central serotonergic
pathways

A

● Blocks seroton

39
Q

CYCLOSPORINE

A

Suppressive host versus graft rejection of heterotrophic
transplanted organ

40
Q

100 times more powerful than cyclosporine

A

TACROLIMUS (FK-506)

41
Q

Antifungal

A

SIROLIMUS (RAPAMYCIN)

42
Q

MYCOPHENOLIC ACID
Prodrug:

A

Prodrug: mycophenolate mofetil

43
Q

Blocks lymphocyte development and proliferation
Supplementary drug for tacrolimus and cyclosporine

A

MYCOPHENOLIC ACID

44
Q

METHOTREXATE
blocks

A

Blocks dihydrofolate reductase

45
Q

reverses methotrexate action

A

Leucovorin

46
Q

Treatment of leukemias and
lymphomas

A

BUSULFAN

47
Q

ANTI-ASTHMATICS also called

A

bronchodilators

48
Q

ACETAMINOPHEN HALF-LIFE:

A

2 hours

49
Q

ASPIRIN HALF-LIFE:

A

3-15 hours

50
Q

Indication: treatment and prevention of severe and
moderate asthma

A

THEOPHYLLINE

51
Q

SIROLIMUS

A

(RAPAMYCIN)

52
Q

● Mechanism central inhibition of prostaglandin
cyclooxygenase
Half life: 3-15 hours 🔊 Peak level for this is 1-2 hours through oral
administration

A

ASPIRIN

CC 2 LEC FINALS (8 decks)

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