TDM

Question 1

Name drugs that require TDM

Answer 1

• digoxin
• aminoglycosides
• vancomycin
• theophylline
• anticonvulsants

Question 2

which drugs are monitored for having a narrow therapeutic index

Answer 2

• theophylline and digoxin

Question 3

examples of anticonvulsants

Answer 3

• phenytoine
• carbemezapines

Question 4

why do we do TDM for anticonvulsants

Answer 4

• they have a high interpersonal variability

Question 5

examples of aminiglycosides and why they get monitored

Answer 5

• gentamycin and amikacin
• they get monitored because they efficacy of the drug relates to the peak concentration and toxicity is also concentration based.

Question 6

reason for vancomycin TDM

Answer 6

• Efficacy is dependent on total drug exposure, efficacy and toxicity relates to trough concentration

Question 7

what makes phenytoin a drug for TDM

Answer 7

• high interpersonal variability
• small dose increase can lead to adverse effects.
• has a zero order kinetic (saturable metabolism)

Question 8

what does drug interpretation depend on

Answer 8

• time of sample collection
• time of last dose
• dosage regimen
• indication for monitoring