TB Flashcards
1
Q
Isoniazid
A
-cidal Inhibits mycolic acid synthesis, pro drug activated by mycobacterial catalase. Inhibits CYP450. Give vitamin B6
2
Q
Rifampin
A
-cidal, inhibits DNA dependant RNA polymerase. Activates CYP450, liver tox Red secretions
3
Q
Streptomycin
A
30S ribosome inhibitor, cannot enter cells, can be used instead of ethambutol
4
Q
Pyrazinamide
A
-cidal inhibits translation, decreases pH, dormant TB
5
Q
Ethambutol
A
-static, inhibits arabinosyl transferase and decreases mycolic acid and increases cell wall permeability, vision problems, contraindicated in kids
6
Q
Pyridoxine
A
vitamin B6, given with isoniazid because it interferes with B6 metabolism.
7
Q
Latent infection treatment
A
rifampin for 4 months, or isoniazid for 9 months.
