TB

Question 1

Name 3 bactericidal Tb drugs in first line treatment

Answer 1

• isoniazid
• rifampicin
• pyrazinamide

Question 2

What type of Tb drug is ethambutol?

Answer 2

Bacteriostatic

Question 3

First line treatment of tb?

Answer 3

2 months intensive phase: ripe
• rifampicin
• isoniazid
• pyrazinamide
• ethambutol
4 months continuation phase with rifampicin and isoniazid

Question 4

Isoniazid moa? (4)

Answer 4

Inhibit synthetic pathways of mycolic acid - component of Tb cell wall
Bactericidal against actively growing Tb bacilli
Bacteriostatic against non-replicating organisms
Must-be activated by catalase peroxidase enzyme

Question 5

Delamanid moa?

Answer 5

Inhibit synthesis of mycobacterial cell wall components (anti-tb)
Bactericidal!
New drug

Question 6

Ae delamanid?

Answer 6

Qt prolongation