taxanes

Question 1

Paclitaxel - give pre treatment with the following drugs

Answer 1

CC
antihistamine
H2 receptor antagonist

this is to prevent severe hypersensitivity reactions; hypersensitivity reactions may occur rarely despite premedication.

Question 2

Docetaxel pre treatment

Answer 2

Pretreatment with dexamethasone by mouth is recommended for reducing fluid retention and hypersensitivity reactions.

Question 3

Carbazitaxel pre treatment

Answer 3

Manufacturer advises pretreatment with a corticosteroid, antihistamine and histamine H2-receptor antagonist to reduce the risk and severity of hypersensitivity reactions.

Question 4

How emetogenic are they

Answer 4

moderate

prophylaxis of delayed n/v = dexa + 5ht3 ant

Question 5

contraception how long

Answer 5

during and 6 months after

Question 6

name some

Answer 6

paclitaxel etc

Question 7

which one is available as different forms

Answer 7

PACLITAXEL

conventional and albumin-bound formulations; these formulations are not interchangeable.

Question 8

what electrolyte disturbance can they cause

Answer 8

hyponatreamia

Question 9

interaction with these AED

Answer 9

Carbamazepine, phenytoin, fosphenytoin, phenobarb, primidone (inducers) is predicted to decrease the exposure to Paclitaxel. Manufacturer advises avoid.

Question 10

interaction with clopidogrel

Answer 10

Clopidogrel is predicted to increase the concentration of Paclitaxel. Manufacturer advises caution.

Question 11

inducers

Answer 11

CRAPGPS e.g. St johns, rifampicin, carb

these decrease lvels. avoid

Question 12

inhibitors

Answer 12

SICKFACES.COM

caution these increase levels of the taxans