bleomycin, mityomycin (cytotoxic abx)

Question 1

bleomycin does not cause…

Answer 1

bone marrow depression (nor does vincristine)

Question 2

mitomycin + vincristine/vinorelbine

Answer 2

increased risk of severe bronchospasm

Question 3

which reactions have been reported

Answer 3

Pulmonary reactions, including interstitial pneumonitis, pulmonary fibrosis, and pulmonary toxicity have been reported.

Question 4

Pulmonary toxicity occurs more frequently in (2)

Answer 4

over 70s
received total doses >400 units

Question 5

what to do if pulmonary changes occur

Answer 5

If pulmonary changes occur, discontinue treatment and investigate.

Question 6

bleomycin contraception

Answer 6

during and 6 months after

Question 7

bleomycin/mitomycin + cisplaitn

Answer 7

Cisplatin increases the risk of pulmonary toxicity when given with Bleomycin. Manufacturer advises caution.

Question 8

Bleomycin or mitomycin-containing cytotoxic regimens might affect the concentration of these AEDs. Manufacturer advises avoid.

Answer 8

fosphenytoin
phenytoin

Question 9

Mitomycin is usually administered at 6-weekly intervals because?

Answer 9

it causes delayed bone-marrow toxicity. Prolonged use may result in a cumulative effect

Question 10

common unusual SE

Answer 10

fever (after administration); fingertip swelling; fingertip tenderness