mycophenolate Flashcards
what is it used for
transplantation and prophylaxis of rejection
what should you do if reccurent infections develop?
Measure serum immunoglobulin
recurrent infections could indicate
Hypogammaglobulinaemia
what is hypogamamglobulinaemia
reduced serum immunoglobulin (antibody) levels
state 2 things it could cause
Hypogammaglobulinaemia or bronchiectasis
what should you consider if persistent respiratory symptoms such as cough and dyspnoea develop.
bronchiectasis or pulmonary fibrosis
interaction with rifampicin
Rifampicin decreases the concentration of Mycophenolate. Manufacturer advises monitor and adjust dose.
monitoring
Monitor full blood count every week for 4 weeks then twice a month for 2 months then every month in the first year (consider interrupting treatment if neutropenia develops).
pt should report signs of bone marrow su ppresion
infection or inexplicable bruising or bleeding.
what would infection or inexplicable bruising or bleeding indicate
bone marrow suppresion
what to do if pure red cell aplasia occurs
Cases of pure red cell aplasia have been reported with mycophenolate mofetil; dose reduction or discontinuation should be considered under specialist supervision.
Pure red cell aplasia (PRCA) is a rare blood disorder where the bone marrow fails to produce red blood cells, leading to severe anemia, while production of other blood cells remains normal.
pregnancy prevention and excluding pregnancy
The MHRA advises to exclude pregnancy in females of CBP before treatment—2 pregnancy tests 8–10 days apart are recommended.
Women should use at least 1 method of effective contraception before and during treatment, and for 6 weeks after discontinuation—2 methods of effective contraception are preferred.
Male patients or their female partner should use effective contraception during treatment and for 90 days after discontinuation.
contraception advice for males
Male patients or their female partner should use effective contraception during treatment and for 90 days after discontinuation.
why should you advice to avoid exposure to sunlight
increased susceptibility to skin cancer (avoid exposure to strong sunlight)
risk of. … (2) when used with other immunosuppressants
risk of hypogammaglobulinaemia or bronchiectasis when used in combination with other immunosuppressants