neural tube defects

Question 1

what is it

Answer 1

Neural tube defects represent a group of congenital defects, caused by incomplete closure of the neural tube within 28 days of conception. The most common forms are anencephaly, spina bifida and encephalocele.

Question 2

main RF

Answer 2

The main risk factors are maternal folate deficiency, maternal vitamin B12 deficiency, previous history of having an infant with a neural tube defect, smoking, diabetes, obesity, and use of antiepileptic drugs

Question 3

prevention in pregnancy

Answer 3

Pregnant women or women who wish to become pregnant should be advised to take supplementation with folic acid before conception and until week 12 of pregnancy.

Question 4

higher daily dose for prevention in pregnancy is recommended for who

Answer 4

A higher daily dose (see folic acid) is recommended for women at a high risk of conceiving a child with a neural tube defect, including women who have previously had an infant with a neural tube defect, who are receiving antiepileptic medication (see Epilepsy), or who have diabetes or sickle-cell disease.