platinum compounds

Question 1

cisplatin contraception and conception

Answer 1

effective contraception during and for at least 6 motnhs after treatment in men and women

Question 2

cisplatin - mild medium or high emetogenicity

Answer 2

high

Question 3

if unexplained respiratory symptoms occur with this drug, discontinue until investigations exclude interstitial lung disease and pulmonary fibrsis

Answer 3

oxaliplatin

Question 4

main SE

Answer 4

neurotoxicity

Question 5

oxilaplatin conception and contraception

Answer 5

during and for 4 months after in women

during and for 6 motnhs after in men

Question 6

cisplatin + bleomyin

Answer 6

Cisplatin increases the risk of pulmonary toxicity when given with Bleomycin. Manufacturer advises caution.
Both Cisplatin and Bleomycin can increase the risk of myelosuppression.

Question 7

what electrolyte disturbance can it cause

Answer 7

hyponatreamia

Question 8

it is …(2)..toxic

Answer 8

nephrotoxic and ototoxic

Question 9

increased risk of ototoxicity with (6)

Answer 9

quinine and derivatives
AGs
loop and thiazides
Amph B
Vancomycin
Vinka alkaloids

Question 10

all intersctions with vinca alkaloids (4)

Answer 10

ototixicty
peripheral neurpathy
myelosuppresion
hyponatreamia

Question 11

interaction with metrnidazole and nitrofursantoin

Answer 11

peripheral neuroapthy