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7361 Hem/Onc Block 1 > Targeted Therapies > Flashcards

Targeted Therapies Flashcards

1
Q

bortezomib (Velcade) primary target?

A

26S proteasome

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2
Q

ixazomib (Nilaro) primary target?

A

26S proteasome

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3
Q

venetoclax (Venclexta) primary target?

A

BCI-2

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4
Q

ponatinib (Iclusig) primary target?

A

BCR-ABL

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5
Q

nilotinib (Tasigna) primary target?

A

BCR-ABL

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6
Q

imatinib (Gleevec) primary target?

A

BCR-ABL

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7
Q

dasatinib (Sprycel) primary target?

A

BCR-ABL

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8
Q

bosutinib (Bosulif) primary target?

A

BCR-ABL

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9
Q

vemurafenib (Zelboraf) primary target?

A

BRAF

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10
Q

dabrafenib (Tafinlar) primary target?

A

BRAF

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11
Q

ibrutinib (Imbruvica) primary target?

A

BTK (Bruton’s tyrosine kinase)

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12
Q

palbociclib (Ibrance) primary target?

A

CDK4/CDK6 (cyclin dependent kinase)

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13
Q

ribociclib (Kisqali) primary target?

A

CDK4/CDK6 (cyclin dependent kinase)

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14
Q

abemaciclib (Verzenio) primary target?

A

CDK4/CDK6 (cyclin dependent kinase)

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15
Q

erlotinib (Tarceva) primary target?

A

EGFR

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16
Q

osimertinib (Tagrisso) primary target?

A

EGFR

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17
Q

crizotinib (Xalkori) primary target?

A

EML4-ALK

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18
Q

alectinib (Alecensa) primary target?

A

EML4-ALK

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19
Q

midostaurin (Rydapt) primary target?

A

FLT3

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20
Q

panobinostat (Farydak) primary target?

A

HDAC

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21
Q

lapatinib (Tykerb) primary target?

A

HER2

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22
Q

trametinib (Mekinist) primary target?

A

MEK

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23
Q

cobimetinib (Cotellic) primary target?

A

MEK

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24
Q

temsirolimus (Torisel) primary target?

A

mTOR

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25
Q

everolimus (Afinitor) primary target?

A

mTOR

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26
Q

thalidomide (Thalomid) primary target?

A

multiple targets

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27
Q

pamalidomide (Pomalyst) primary target?

A

multiple targets

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28
Q

lenalidomide (Revlimid) primary target?

A

multiple targets

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29
Q

olaparib (Lynparza) primary target?

A

PARP

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30
Q

niraparib (Zejula) primary target?

A

PARP

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31
Q

idelalisib (Zydelig) primary target?

A

PI3K-delta

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32
Q

sunitinib (Sutent) primary target?

A

VEGFR2

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33
Q

regorafenib (Stivarga) primary target?

A

VEGFR2

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34
Q

pazopanib (Votrient) primary target?

A

VEGFR2

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35
Q

sorafenib (Nexavar) primary target?

A

VEGFR2

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36
Q

axitinib (Inlyta) primary target?

A

VEGFR2

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37
Q

cabozanitinib (Cabometyx) primary target?

A

VEGFR2

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38
Q

venetoclax target class?

A

anti-apoptotic protein inhibitor

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39
Q

Drugs that target BCR-ABL fall into what class?

A

kinase inhibitors

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40
Q

Drugs that target BRAF fall into what class?

A

kinase inhibitors

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41
Q

Drugs that target BTK fall into what class?

A

kinase inhibitor

ibrutinib

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42
Q

Drugs that target CDK4/CDK6 fall into what class?

A

kinase inhibitor

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43
Q

Drugs that target EGFR fall into what class?

A

kinase inhibitors

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44
Q

Drugs that target EML-4-ALK fall into what class?

A

kinase inhibitors

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45
Q

Drugs that target FLT3 fall into what class?

A

kinase inhibitor

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46
Q

Drugs that target HDAC fall into what class?

A

enzyme inhibitor

panobinostat

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47
Q

Drugs that target HER2 fall into what class?

A

kinase inhibitors

48
Q

Drugs that target MEK fall into what class?

A

kinase inhibitor

trametinib, cobimetinib

49
Q

Drugs that target mTOR fall into what class?

A

kinase inhibitors

temsirolimus, everolimus

50
Q

Thalidomide, pamilidomsde, and lenalidomide fall into what class?

A

immunomodulatory amide drugs (IMiDs)

51
Q

Drugs that target PARP fall into what class?

A

enzyme inhibitor

olaparib, niraparib

52
Q

Drugs that target PI3K-delta fall into what class?

A

kinase inhibitor

idelalisib

53
Q

Drugs that target VEGFR2 fall into what class?

A

kinase inhibitors

sunitinib, regorafenib, pazopanib, sorafenib, axitinib, cabozantinib

54
Q

bortezomib is used to treat what two diseases?

A

multiple myeloma

mantle cell lymphoma

55
Q

ixazomib is used to treat what disease?

A

multiple myeloma

56
Q

venetoclax is used to treat what two diseases?

A

certain leukemias

certain lymphomas

57
Q

ponatinib is used to treat what two diseases?

A

Ph+ CML

Ph+ AML

58
Q

nilotinib is used to treat what disease?

A

Ph+ CML

59
Q

imatinib is used to treat what 3 diseases?

A

Ph+ CML
Ph+ AML
GIST (due to c-KIT activity)

60
Q

dasatinib is used to treat what two diseases?

A

Ph+ CML

Ph+ AML

61
Q

bosutinib is used to treat what disease?

A

Ph+ CML

62
Q

vemurafenib is used to treat what disease?

A

V600E melanoma

63
Q

dabrafenib is used to treat what disease?

A

V600E melanoma

64
Q

ibrutinib is used to treat what disease?

A

B-cell lymphomas and leukemias

65
Q

palbociclib is used to treat what disease?

A

HR+, HER2 negative breast cancer

66
Q

ribociclib is used to treat what disease?

A

HR+, HER2 negative breast cancer

67
Q

abemaciclib is used to treat what disease?

A

HR+, HER2 negative breast cancer

68
Q

erlotinib is used to treat what disease?

A

NSCLC with EGFR activating mutations

69
Q

osimertinib is used to treat what disease?

A

NSCLC with EGFR activating mutations

70
Q

crizotinib is used to treat what disease?

A

NSCLC with EML4-ALK

71
Q

alectinib is used to treat what disease?

A

NSCLC with EML4-ALK

72
Q

midostaurin is used to treat what disease?

A

AML with FLT3 activating mutations

73
Q

panobinostat is used to treat what disease?

A

multiple myeloma

74
Q

lapatinib is used to treat what disease?

A

HER2+ breast cancer

75
Q

trametinib is used to treat what disease?

A

V600E melanoma

76
Q

cobimetinib is used to treat what disease?

A

V600E melanoma

77
Q

temsirolimus is used for?

A

post transplant immunosuppressive therapy and certain cancers

78
Q

everolimus is used for?

A

post transplant immunosuppressive therapy and certain cancers

79
Q

thalidomide is used to treat?

A

multiple myeloma

80
Q

pamalidomide is used to treat?

A

multiple myeloma

81
Q

lenalidomide is used to treat?

A

multiple myeloma

82
Q

olaparib is used to treat?

A

BRCA mutated breast or ovarian cancer

83
Q

niraparib is used to treat?

A

BRCA mutated breast or ovarian cancer

84
Q

idelalisib is used to treat?

A

CLL and NHL

85
Q

sunitinib is used to treat what 3 diseases?

A

RCC
pancreatic cancer
GIST (due to c-KIT activity)

86
Q

regorafenib is used to treat?

A

metastatic colon cancer

87
Q

pazopanib is used to treat what 2 things?

A

RCC

soft tissue sarcomas

88
Q

sorafenib is used to treat 3 things?

A

RCC
thyroid cancer
hepatocellular carcinoma

89
Q

axitinib is used to treat?

A

RCC

90
Q

cabozantinib is used to treat?

A

RCC

91
Q

__ has a BBW for arterial thrombosis and hepatotoxicity

A

ponatinib

92
Q

__ has a BBW for QT prolongation

A

nilotinib

93
Q

__ has a BBW for severe diarrhea and potentially fatal cardiac events

A

panobinostat

94
Q

lapatinib has a BBW for __

A

hepatotoxicity

95
Q

thalidomide has a BBW for __

A

severe birth defects, thromboembolism

96
Q

pamalidomide has a BBW for __

A

severe birth defects, thromboembolism

97
Q

lenalidomide has a BBW for __

A

severe birth defects
thromboembolism
myelosuppression

98
Q

___ has a BBW for hepatotoxicity, pneumonitis, and GI distress

A

idelalisib

99
Q

sunitinib has a BBW for ___

A

hepatotoxicity

100
Q

regorafenib has a BBW for ___

A

hepatotoxicity

101
Q

pazopanib has a BBW for __

A

hepatotoxicity

102
Q

Which two agents can cause acneiform rash?

A

erlotinib

lapatinib

103
Q

__ should be taken with a low fat meal

A

regorafenib

increases exposure

104
Q

ixazomib should be taken with or without food?

A

without

take on empty stomach

105
Q

venetoclax should be taken with or without food?

A

with food

increases exposure

106
Q

nilotinib should be taken with or without food?

A

without food

take on empty stomach

107
Q

bosutinib should be taken with or without food?

A

with food

108
Q

erlotinib should be taken with or without food?

A

without food

take on em[pty stomach

109
Q

midostaurin should be taken with or without food?

A

take twice daily with food

110
Q

lapatinib should be taken with or without food?

A

without food

take on empty stomach

111
Q

trametinib should be taken with or without food?

A

without food

take on empty stomach

112
Q

sorafenib should be taken with or without food?

A

without food

take on empty stomach

113
Q

__ is effective against T315I mutant

A

ponatinib

114
Q

__ is an irreversible inhibitor

A

ibrutinib

115
Q

__ contains a boronic functional group and is dosed IV

A

bortezomib

osimertinib

116
Q

___ is effective versus T790M gatekeeper mutan

A

osimertinib

irreversible inhibitor

7361 Hem/Onc Block 1 (9 decks)

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