Biologics Flashcards
Biologics are similar to small molecule chemo drugs.
a. true
b. false
b. false
biologics are totally different from small molecule chemo drugs
What is a key mechanism of biologics for cancer therapy?
to induce the body’s immune system to recognize and attack cancer cells
What is the brand name of recombinant IL2?
Proleukin
How does IL2 work against cancer?
endogenous and exogenous activate T cells and NK cells
What is brand name of recombinant human IFN alpha 2 b?
Heberon alfa R
What is brand name of IFN alpha 2b?
Intron-A
What is used to treat viral infections and cancers such as chronic hep C/B, hairy cell leukemia, etc?
interferon alfa 2b
2 antibody drug conjugates:
gemtuzumab
ibritumomab
Suffix for human mabs?
-mumab
Suffix for chimeric mabs?
-ximab
suffix for mouse mabs?
-momab
suffix for humanized mabs?
-zumab
List the types of antibody according to their potency in induction of immunological reactions inside human body, from the strongest to the weakest:
mouse (momab), chimeric (ximab), humanized (zumab), human (mum)
Antibodies can be __ with a variety of substances to enhance anticancer effects, including chemo-drugs, protein toxins, radionuclides, prodrug-activating enzymes, etc.
conjugated
ado-trastuzumab emtanvine target?
HER2
bevacizumab target?
VEGF ligand
cetuximab target?
EGFR
daratumumab target?
PD-1
CD38
elotuzumab target?
SLAMF7
gemtuzumab target?
CD33
ipilimumab target?
CTLA-4
obinutuzumab target?
CD20
panitumumab target?
EGFR
pembrolizumab target?
PD-1
pertuzumab target?
HER2
rituxumab target?
CD20
trastuzumab target?
HER2
bevacizumab brand name?
Avastin
bevacizumab (Avastin) blocks what?
angiogenesis
inhibits VEGF-A
pembrolizumab brand name?
Keytruda
Which mab targets the programmed cell death protein (PD-1) of lymphocytes?
pembrolizumab (Keytruda)
Which mab is FDA approved for any unresectable/metastatic solid tumor with certain genetic anomalies?
pembrolizumab (Keytruda)
bevacizumab (Avastin) is approved for use with __ therapy for second line metastatic colorectal cancer
5-FU
Which mab is approved for non squamous non small cell lung cancer in combo with carboplatin/paclitaxel?
bevacizumab (Avastin)
Which mab is approved for treatment of metastatic renal cell cancer and recurrent glioblastoma multiform?
bevacizumab (Avastin)
What mab is an antibody drug conjugate of cytotoxic DM1?
ado-trastuzumab emtanvine (T-DM1)
What is rand name of ado-trastuzumab?
Kadcyla
What is brand name of ibritumomab?
Zevalin
What mab is radioimmunotherapy Tx formed by mouse IgG1 conjugated with tiuxetan?
ibritumomab
Which mab is conjugated to Yttrium-90?
ibritumomab
Why do antibody targets (epitopes) need to be on the cell surface?
antibody based drugs cannot penetrate the cell membrane
Targeting PD-1 (pembrolizumab) causes what?
elevated production of autocrine paracrine cytokines, causing greater cytotoxicity
Two therapies that are only highly effective in a small subpopulation of cancer pts with biomarkers?
CTLA-4
PD-1
Therapeutic cancer vaccine (tCV) prevents cancer occurrence.
a. true
b. false
b. false
What is the brand name of the first cell based therapeutic cancer vaccine?
Provenge
sipuleucel-T
personalized medicine
What is brand name of first CAR-T cell therapy?
Kymriah
tisagenlecleucel
personalized medicine
What is T-VEC?
first oncolypic viral therapy
What is the brand name of oncolypic viral therapy, T-VEC?
Imlygic
How is T-VEC (Imlygic) administered?
directly injected into melanoma tumors
