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7361 Hem/Onc Block 1 > Biologics > Flashcards

Biologics Flashcards

1
Q

Biologics are similar to small molecule chemo drugs.

a. true
b. false

A

b. false

biologics are totally different from small molecule chemo drugs

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2
Q

What is a key mechanism of biologics for cancer therapy?

A

to induce the body’s immune system to recognize and attack cancer cells

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3
Q

What is the brand name of recombinant IL2?

A

Proleukin

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4
Q

How does IL2 work against cancer?

A

endogenous and exogenous activate T cells and NK cells

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5
Q

What is brand name of recombinant human IFN alpha 2 b?

A

Heberon alfa R

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6
Q

What is brand name of IFN alpha 2b?

A

Intron-A

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7
Q

What is used to treat viral infections and cancers such as chronic hep C/B, hairy cell leukemia, etc?

A

interferon alfa 2b

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8
Q

2 antibody drug conjugates:

A

gemtuzumab

ibritumomab

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9
Q

Suffix for human mabs?

A

-mumab

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10
Q

Suffix for chimeric mabs?

A

-ximab

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11
Q

suffix for mouse mabs?

A

-momab

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12
Q

suffix for humanized mabs?

A

-zumab

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13
Q

List the types of antibody according to their potency in induction of immunological reactions inside human body, from the strongest to the weakest:

A

mouse (momab), chimeric (ximab), humanized (zumab), human (mum)

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14
Q

Antibodies can be __ with a variety of substances to enhance anticancer effects, including chemo-drugs, protein toxins, radionuclides, prodrug-activating enzymes, etc.

A

conjugated

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15
Q

ado-trastuzumab emtanvine target?

A

HER2

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16
Q

bevacizumab target?

A

VEGF ligand

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17
Q

cetuximab target?

A

EGFR

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18
Q

daratumumab target?

A

PD-1

CD38

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19
Q

elotuzumab target?

A

SLAMF7

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20
Q

gemtuzumab target?

A

CD33

21
Q

ipilimumab target?

A

CTLA-4

22
Q

obinutuzumab target?

A

CD20

23
Q

panitumumab target?

A

EGFR

24
Q

pembrolizumab target?

A

PD-1

25
Q

pertuzumab target?

A

HER2

26
Q

rituxumab target?

A

CD20

27
Q

trastuzumab target?

A

HER2

28
Q

bevacizumab brand name?

A

Avastin

29
Q

bevacizumab (Avastin) blocks what?

A

angiogenesis

inhibits VEGF-A

30
Q

pembrolizumab brand name?

A

Keytruda

31
Q

Which mab targets the programmed cell death protein (PD-1) of lymphocytes?

A

pembrolizumab (Keytruda)

32
Q

Which mab is FDA approved for any unresectable/metastatic solid tumor with certain genetic anomalies?

A

pembrolizumab (Keytruda)

33
Q

bevacizumab (Avastin) is approved for use with __ therapy for second line metastatic colorectal cancer

A

5-FU

34
Q

Which mab is approved for non squamous non small cell lung cancer in combo with carboplatin/paclitaxel?

A

bevacizumab (Avastin)

35
Q

Which mab is approved for treatment of metastatic renal cell cancer and recurrent glioblastoma multiform?

A

bevacizumab (Avastin)

36
Q

What mab is an antibody drug conjugate of cytotoxic DM1?

A

ado-trastuzumab emtanvine (T-DM1)

37
Q

What is rand name of ado-trastuzumab?

A

Kadcyla

38
Q

What is brand name of ibritumomab?

A

Zevalin

39
Q

What mab is radioimmunotherapy Tx formed by mouse IgG1 conjugated with tiuxetan?

A

ibritumomab

40
Q

Which mab is conjugated to Yttrium-90?

A

ibritumomab

41
Q

Why do antibody targets (epitopes) need to be on the cell surface?

A

antibody based drugs cannot penetrate the cell membrane

42
Q

Targeting PD-1 (pembrolizumab) causes what?

A

elevated production of autocrine paracrine cytokines, causing greater cytotoxicity

43
Q

Two therapies that are only highly effective in a small subpopulation of cancer pts with biomarkers?

A

CTLA-4

PD-1

44
Q

Therapeutic cancer vaccine (tCV) prevents cancer occurrence.

a. true
b. false

A

b. false

45
Q

What is the brand name of the first cell based therapeutic cancer vaccine?

A

Provenge

sipuleucel-T

personalized medicine

46
Q

What is brand name of first CAR-T cell therapy?

A

Kymriah

tisagenlecleucel

personalized medicine

47
Q

What is T-VEC?

A

first oncolypic viral therapy

48
Q

What is the brand name of oncolypic viral therapy, T-VEC?

A

Imlygic

49
Q

How is T-VEC (Imlygic) administered?

A

directly injected into melanoma tumors

7361 Hem/Onc Block 1 (9 decks)

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