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7361 Hem/Onc Block 1 > Biologic Short List - Apes Together Strong > Flashcards

Biologic Short List - Apes Together Strong Flashcards

1
Q

ado-trastuzumab emtansine

What is it?

A

humanized monoclonal antibody-drug conjugate

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2
Q

brentuximab

What is it?

A

chimeric monoclonal antibody-drug conjugate

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3
Q

gemtuzumab ozogamicin

What is it?

A

humanized antibody-drug conjugate

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4
Q

interferon alpha2b

what is it?

A

recombinant cytokine signaling PROTEIN

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5
Q

interleukin 2 (IL-2)

what is it?

A

recombinant cytokine signaling MOLECULE

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6
Q

sipuleucel-T

what is it?

A

cell-based cancer immunotherapy (vaccine)

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7
Q

T-VEC

what is it?

A

engineered oncolytic virus

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8
Q

What are the major sources of IL-2?

A

activated CD4 and CD8 T cells

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9
Q

What was the first effective anticancer immunotherapy?

A

IL-2

stimulates T cells and NK cells to attack cancer

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10
Q

Which therapy is being tested in clinical trials to treat Covid?

A

interferon alpha-2b

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11
Q

__ blocks angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A)

A

bevacizumab

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12
Q

__ targets the PD-1 receptor of lymphocytes

A

pembrolizumab

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13
Q

Which antibody-drug conjugate consists of cytotoxic DM1 covalently linked to a humanized mab?

A

ado-trastuzumab emtansine

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14
Q

Which antibody-drug conjugate is a radioimmunotherapy treatment formed by mouse IgG1 conjugated with tiuxetran (loaded wit Yttrium-90)?

A

ibritumomab

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15
Q

Why do antibody targets need to be on the cell surface?

A

antibody based drugs cannot penetrate cell membrane

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16
Q

How does targeting/blocking PD-1 achieve anticancer effects

A

elevates autocrine/paracrine cytokines causing enhanced cytotoxicity

17
Q

Which drug targets PD-1?

A

pembrolizumab

18
Q

Does sipuleucel-T (TCV) prevent cancer?

A

no

19
Q

__ is based on engineered dendritic cells expressing highly immunogenic antigens

A

Sipuleucel-T

cell-based therapeutic cancer vaccine

20
Q

__ is the first CAR-T cell therapy

A

tisagenlecluecel (Kymriah)

personalized medicine

T cells isolated from pt’s blood, CAR gene inserted, cells grown in culture, infused back into pt

21
Q

How is T-VEC administered?

A

injected into melanoma tumors

oncolytic viral therapy

22
Q

What cancer genotypes does T-VEC attack?

A

all of them

attacks regardless of cancer genotype

7361 Hem/Onc Block 1 (9 decks)

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