Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

7361 Hem/Onc Block 1 > Chemotherapeutic Drugs > Flashcards

Chemotherapeutic Drugs Flashcards

1
Q

chlorambucil drug class?

A

nitrogen mustard DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

bendamustine drug class?

A

nitrogen mustard DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

melphalan drug class?

A

nitrogen mustard DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

cyclophosphamide drug class?

A

nitrogen mustard DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ifosfamide drug class?

A

nitrogen mustard DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

busulfan drug class?

A

(bis)methylsulfonate ester DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

carmustine drug class?

A

nitrosurea DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

lomustine drug class?

A

nitrosurea DNA alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

dacarbazine drug class?

A

DNA methylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

temozolomide drug class?

A

DNA methylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

procarbazine drug class?

A

DNA methylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

cisplatin drug class?

A

platinum agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

carboplatin drug class?

A

platinum agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

oxaliplating drug class?

A

platinum agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

bleomycin drug class?

A

DNA intercalation agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ironotecan drug class?

A

camptothecin topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

topotecan drug class?

A

camptothecin topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

etoposide drug class?

A

epipodophyllotoxin topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

teniposide drug class?

A

epipodophyllotoxin topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

doxorubicin drug class?

A

anthracycline topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

epirubicin drug class?

A

anthracycline topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

valrubicin drug class?

A

anthracycline topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

daunorubucin drug class?

A

anthracycline topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

idarubicin drug class?

A

anthracycline topoisomerase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

mitoxantrone drug class?

A

anthracenedione topoisomerase inhibitor

do not confuse with anthraCYCLINE topo inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

arsenic trioxide drug class?

A

heavy metal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

hydroxyurea drug class?

A

cytotoxic enzyme inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

5-fluorouracil drug class?

A

pyrimidine antimetabolite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

capecitabine drug class?

A

pyrimidine antimetabolite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

cytarabine drug class?

A

cytidine antimetabolite

31
Q

gemcitabine drug class?

A

cytidine antimetabolite

32
Q

azacytidine drug class?

A

cytidine antimetabolite

33
Q

decitabine drug class?

A

cytidine antimetabolite

34
Q

mercaptopurine drug class?

A

purine antimetabolite

35
Q

fludarabine drug class?

A

purine antimetabolite

36
Q

cladribine drug class?

A

purine antimetabolite

37
Q

methotrexate drug class?

A

antifolate

38
Q

pemetrexed drug class?

A

antifolate

39
Q

pralatrexate drug class?

A

antifolate

40
Q

leucovorin drug class?

A

folate

41
Q

levoleucovorin drug class?

A

folate

42
Q

allopurinol drug class?

A

xanthine oxidase inhibitor

43
Q

paclitaxel drug class?

A

taxane antimitotic

44
Q

docetaxel drug class?

A

taxane anti mitotic

45
Q

cabazitaxel drug class?

A

taxane antimitotic

46
Q

vincristine drug class?

A

vinca alkaloid antimitotic

47
Q

vinblastine drug class?

A

vinca alkaloid antimitotic

48
Q

vinorelbine drug class?

A

vinca alkaloid anti mitotic

49
Q

ixabepilone drug class?

A

epothilone anti mitotic

50
Q

MOA of nitrogen mustard DNA alkylating agents?

A

alkylation of N7 of guanine nucleases leading to formation of INTERstrand cross-links

chlorambucil, bendamustine, melphalan, cyclophosphamide, ifosfamide

51
Q

MOA of busulfan?

A

alkylation of N7 guanine nucleases leading to formation of INTERstrand cross links

same as nitrogen mustards

52
Q

MOA of nitrosurea DNA alkylating agents carmustine and lomustine?

A

Lkylation of O6 guanine nucleobases leading to INTERstrand cross links

53
Q

MOA of DNA methylating agents dacarbazine, temozolomide, procarbazine?

A

methylation of O6 guanine nucleobases

54
Q

MOA of platinum agents cisplatin, carboplatin, oxaliplatin?

A

alkylation of DNA leading to INTRAstrand cross links

55
Q

MOA of DNA intercalation agent bleomycin?

A

causes DNA free radicals that lead to strand breaks

56
Q

MOA of ironotecan and topotecan?

A

bind and stabilize DNA TOPOISOMERASE I, blocking the resealing of SINGLE strand breaks

57
Q

MOA of etoposide, etoposide phosphate, teniposide?

A

bind and stabilize DNA TOPOISOMERASE II, blocking resealing of DOUBLE strand breaks

epidopophyllotoxin topoisomerase inhibitors

58
Q

MOA of doxorubicin, epirubicin, valrubicin, daunorubicin, idarubicin?

A

bind and stabilize DNA TOPOISOMERASE II, blocking resealing of DOUBLE strand breaks

anthracycline topoisomerase inhibitors

59
Q

MOA of mitoxantrone?

A

bind and stabilize the DNA TOPOISOMERASE II complex, blocking resealing of DOUBLE strand breaks

anthraCENDEDIONE topoisomerase inhibitor

same MOA as anthracyclines

60
Q

MOA of the heavy metal arsenic trioxide?

A

destruction of fusion protein from reciprocal translocation of chromosomes 15 and 17

61
Q

MOA of hydroxyurea?

A

ribonucleotide reductase inhibitor

cytotoxic enzyme inhibitor

62
Q

MOA of 5-fluorouracil?

A

thymidylate synthase inhibitor

pyrimidine antimetabolite

63
Q

capecitabine MOA?

A

thymidylate synthase inhibitor (oral prodrug for 5-FU)

64
Q

Which drug is an oral prodrug for 5-FU?

A

capecitabine

65
Q

MOA of cytidine antimetabolites cytarabine, gemcitabine?

A

DNA polymerase inhibitors

66
Q

MOA of azacytidine and decitabine?

A

DNA methyltransferase inhibitors

cytarabine and gemcitabine are polymerase inhibitors

67
Q

MOA of purine antimetabolites mercaptopurine?

A

Tase inhibitor, which blocks biosynthesis of AMP and GMP

68
Q

MOA of purine antimetabolites fludarabine and cladribine?

A

DNA polymerase inhibitor

69
Q

MOA of methotrexate, pemetrexed, and pralatrexate?

A

dihydrofolate reductase (DHFR) inhibitors

antifolates

70
Q

MOA of folate leucovorin and levoleucovorin?

A

enhance activity of 5-FU

folates

71
Q

allopurinol is used to increase __ exposure

A

mercaptopurine

72
Q

MOA of taxane anti mitotics paclitaxel, docetaxel, cabazitaxel?

A

promote microtubule assembly and stabilize microtubules thus inhibiting disassembly

taxane antimitotics

73
Q

MOA of vinca alkaloid antimitotics vincristine, vinblastine, vinorelbine?

A

inhibition of microtubule assembly

74
Q

MOA of epothilone anti mitotic ixabepilone?

A

promote microtubule assembly and stabilize microtubules, thus inhibiting their disassembly

7361 Hem/Onc Block 1 (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions