targete therapy

Question 1

hormonal modifiers

Answer 1

1) corticosteroid modifiers
2) estrogen antagonists
3) aromatase inhibitors
4) antiandrogen

Question 2

corticosteroid modifiers example

Answer 2

prednisone

Question 3

estrogen antagonists example

Answer 3

tamoxifen/ raloxifene
- adenocarcinoma of the breast

Question 4

aromatase inhibitors example

Answer 4

1) exemestane, anastrozole
- inhibitors of estrogen synthesis

Question 5

antiandrogen example

Answer 5

1) flutamide, bicalutamide
- prostate cancer

Question 6

cytokine therapy

Answer 6

1) stimulate production of cells that prevent tumor growth
2) IL-2
- T cell and NK stimulator
3) INF-alpha
- inhibit tumor growth
- NK cells and APC activation

Question 7

cancer cell inhibitors

Answer 7

1) monoclonal antibodies
2) small molecule inhibitors

Question 8

monoclonal antibodies example

Answer 8

1) rituximab
- blocks CD20
2) trastuzumab
- blocks Her-neu
3) bevacizumab
- binds VEGF

Question 9

small molecule inhibitors

Answer 9

1) bortezomib
- proteosome inhibitor
2) imatinib
- tyrosine kinase inhibitors
3) sunitinib
- angiogenesis inhibitor

Question 10

tumor blood vessels

Answer 10

1) fewer supporting cells
2) occlusion

Question 11

chemotherapeutic dosing schedule

Answer 11

1) MTD pulsatile chemotherapy ( every 3 weeks)
2) metronomic chemo
- lower dose on a weekly basis
3) metronomic chemitherapy
- lower dose on a daily basis

Question 12

VEGF pathway inhibitors adverse effects

Answer 12

1) impaired wound healing
2) arterial thromboembolic events
3) increase bruising
4) xerostomia, stomatitis, mucositis
5) altered taste, dysphagia
6) cytochrome interactions

Question 13

other treatments

Answer 13

1) vaccines being developed
- HPV, prostate