Tackling maladaptive memories through reconsolidation: from neural to clinical science Flashcards
the traditional model of memory involves…
the transition from short-term to long-term memory through consolidation, primarily mediated by protein synthesis
wat is nu het nieuwe model van memory
reactivation-induced memory reconsolidation: allowing modification or disruption of consolidated memories via propranolol.
the observed fear modification was durable, and resistant to reinstatement or spantaneous recovery, even when administered after memory reactivation.
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wat zijn challenges
inconsistent results, small sample sizes, need to control for alternative explanations.
welke receptor is verantwoordelijk voor wat
NMDA = labialisation of a fear memory trace upon reactivation
AMPA = memory expression
prediction error seems to be even more important than absence of reinforcement
oke, dus belangrijker om fout bewezen te worden dan dat je nooit meer de reinforcement krijgt.
the optimal amount of prediction error is still uncertain
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wat is de relatie tussen prediction error, reconsolidation and extinction
reactivation is not synonymous with reconsolidation, and prediction error during reactivation does not always guarantee reconsolidation; it can also lead to extinction. the length and nature of the reactivation determine the outcome: longer reactivations tend to result in extinction, whilst shorter reactivations are more likely to trigger reconsolidation.
the same session can trigger reconsolidation in one person, extinction in another
oke dat maakt het dus wel lastig
wat zijn dus nadelen
- lastig omdat de duration niet duidelijk is voor reconsolidation (kan zo naar extinction gaan)
- weinig onderzoek met complexe memories, alleen simplistic and recent -> real-world complexity
- niet altijd goede resultaten
- longevity of symptom improvement?
kijken naar the fate of memory after reactivation in schrift
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