TABLETS II Flashcards
are flat, oval tablets intended to be dissolved in the buccal pouch (buccal tablets) or beneath the tongue (sublingual tablets) for absorption through the oral mucosa.
Buccal and Sublingual tablets
They enable oral absorption of drugs that are destroyed by the gastric juice and/or are poorly absorbed from the gastrointestinal tract.
Buccal and Sublingual tablets
are designed to erode slowly
Buccal
dissolve promptly and provide rapid drug effects.
Sublingual tablets
They are intended to be slowly dissolved in the oral cavity, usually for local effects, although some are formulated for systemic absorption.
Buccal and Sublingual tablets
Lozenges or troches are disc-shaped solid dosage forms containing a medicinal agent and generally a flavoring substance in a hard candy or sugar base.
Buccal and Sublingual tablets
Have a smooth, rapid disintegration when chewed or allowed to dissolve in the mouth, have a creamy base, usually of specially flavored and colored mannitol
Chewable Tablets
Useful for administration of large tablets to children and adults who have difficulty swallowing solid dosage form
Chewable Tablets
Prepared by compressing granular effervescent salts that release gas when in contact with water.
Effervescent tablets
Generally contain medicinal substances that dissolve rapidly when added to water.
Effervescent tablets
can assist in breaking up the tablets and enhancing the dissolution of the active drug.
bubble chain
Certain tablets, such as tablet triturates, may be prepared by molding rather than by compression
Molded tablets
The resultant tablets are very soft and soluble and are designed for rapid dissolution
Molded tablets
The few tablet triturates that remain are used sublingually, such as NTG tablets.
Tablet Triturates
Small, usually cylindrical, molded, or compressed tablets containing small amounts of usually potent drugs
Tablet Triturates
A combination of sucrose and lactose is usually the diluent.
Tablet Triturates
Originally used by physicians in extemporaneous preparation of parenteral solution
Hypodermic tablets
the tablets were a convenience, since they could be easily carried in the physician’s medicine bag and injections prepared to meet the needs of the individual patients.
Hypodermic tablets
The required number of tablets was dissolved in a suitable vehicle, sterility attained, and the injection performed.
Hypodermic tablets
However, the difficulty in achieving sterility and the availability of prefabricated injectable products, some in disposable syringes, have eliminated the need for hypodermic tablets.
Hypodermic tablets
Designed to disintegrate and release their medication with no special rate-controlling features, such as special coatings and other techniques
Immediate-Release tablets
characterized by disintegrating or dissolving in the mouth within 1 minute, some within 10 seconds
Rapidly Disintegrating or Dissolving Tablets
There are no standards that define an RDT, but one possibility is dissolution in the mouth within approximately 15 seconds; anything slower would not be categorized as rapidly dissolving.
Rapidly Disintegrating or Dissolving Tablets
Designed to release their medication in a predetermined manner over an extended period
Extended-Release tablets
Tablets of this type are designed for children and the elderly or for any patient who has difficulty in swallowing tablets. They liquefy on the tongue, and the patient swallows the liquid
Rapidly Disintegrating or Dissolving Tablets
Vaginal inserts, are uncoated, bullet-shaped, or ovoid tablets inserted into the vagina for local effects.
Vaginal tablets
They are prepared by compression and shaped to fit snugly on plastic inserter devices that accompany the product.
Vaginal tablets
