TABLETS I Flashcards
solid dosage forms usually prepared with the aid of suitable pharmaceutical excipients
TABLETS
are manufactured with tablet machines capable of exerting great pressure in compacting the powdered or granulated material
compressed
are prepared on a large scale by tablet machinery or on a small scale
molded
which add the necessary bulk to a formulation to prepare tablets of the desired size
diluents
which promote adhesion of the particles of the formulation, allowing a granulation to be prepared and maintaining the integrity of the final tablet
binders
which promote breakup of the tablets after administration to smaller particles for ready drug availability
disintegrants
which enhance the flow of the material into the tablet dies, minimize wear of the punches and dies, prevent fill material from sticking to the punches and dies, and produce tablets with a sheen
lubricating agents
such as colorants and flavorants
miscellaneous adjuncts
Prepared by subjecting the fill material to more than a single compression
Multiple Compressed Tablets
May be a multiple- layer tablet or a tablet within a tablet, the inner tablet being the core and the outer portion being the shell
Multiple Compressed Tablets
In preparation of tablets within tablets, special machines are required to place the preformed core tablet precisely within the die for application of surrounding fill material
Multiple Compressed Tablets
Each layer may contain a different medicinal agent, separated for reasons of chemical or physical incompatibility, staged drug release, or simply the unique appearance of the layered tablet
Multiple Compressed Tablets
Compressed tablets may be coated with a colored or an uncolored sugar layer
Sugarcoated tablets
The coating is water soluble and quickly dissolves after swallowing.
Sugarcoated tablets
protects the enclosed drug from the environment and provides a barrier to objectionable taste or odor.
Sugarcoated tablets
enhances the appearance of the compressed tablet and permits imprinting of identifying manufacturer’s information
Sugarcoated tablets
Among the disadvantages to sugarcoating tablets are the time and expertise required in the coating process and the increase in size, weight, and shipping costs
Sugarcoated tablets
may add 50% to the weight and bulk of the uncoated tablet
Sugarcoated tablets
Compressed tablets coated with a thin layer of a polymer capable of forming a skin-like film.
Film-Coated tablets
The film is usually colored and has the advantage over sugarcoatings in that it is more durable, less bulky, and less time-consuming to apply
Film-Coated tablets
By its composition, the coating is designed to rupture and expose the core tablet at the desired location in the gastrointestinal tract
Film-Coated tablets
facilitates swallowing, and gelatin- coated tablets are more tamper evident than unsealed capsules
Gelatin-coated tablets
The innovator product, the gelcap, is a capsule-shaped compressed tablet that allows the coated product to be about one-third smaller than a capsule filled with an equivalent amount of powder
Gelatin-coated tablets
Examples include Tylenol Cold Multi-Symptom Daytime
Gelatin-coated tablets
Have delayed-release features
Enteric-coated tablets
They are designed to pass unchanged through the stomach to the intestines, where the tablets disintegrate and allow drug dissolution and absorption and/or effect.
Enteric-coated tablets
are employed when the drug substance is destroyed by gastric acid or is particularly irritating to the gastric mucosa or when bypass of the stomach substantially enhances drug absorption
Enteric-coated tablets
do not dissolve in acidic condition
Enteric-coated tablets
readily dissolve in alkaline ph
Enteric-coated tablets
