TABLETS I

Question 1

solid dosage forms usually prepared with the aid of suitable pharmaceutical excipients

Answer 1

TABLETS

Question 2

are manufactured with tablet machines capable of exerting great pressure in compacting the powdered or granulated material

Answer 2

compressed

Question 3

are prepared on a large scale by tablet machinery or on a small scale

Answer 3

molded

Question 4

which add the necessary bulk to a formulation to prepare tablets of the desired size

Answer 4

diluents

Question 5

which promote adhesion of the particles of the formulation, allowing a granulation to be prepared and maintaining the integrity of the final tablet

Answer 5

binders

Question 6

which promote breakup of the tablets after administration to smaller particles for ready drug availability

Answer 6

disintegrants

Question 7

which enhance the flow of the material into the tablet dies, minimize wear of the punches and dies, prevent fill material from sticking to the punches and dies, and produce tablets with a sheen

Answer 7

lubricating agents

Question 8

such as colorants and flavorants

Answer 8

miscellaneous adjuncts

Question 9

Prepared by subjecting the fill material to more than a single compression

Answer 9

Multiple Compressed Tablets

Question 10

May be a multiple- layer tablet or a tablet within a tablet, the inner tablet being the core and the outer portion being the shell

Answer 10

Multiple Compressed Tablets

Question 11

In preparation of tablets within tablets, special machines are required to place the preformed core tablet precisely within the die for application of surrounding fill material

Answer 11

Multiple Compressed Tablets

Question 11

Each layer may contain a different medicinal agent, separated for reasons of chemical or physical incompatibility, staged drug release, or simply the unique appearance of the layered tablet

Answer 11

Multiple Compressed Tablets

Question 12

Compressed tablets may be coated with a colored or an uncolored sugar layer

Answer 12

Sugarcoated tablets

Question 13

The coating is water soluble and quickly dissolves after swallowing.

Answer 13

Sugarcoated tablets

Question 14

protects the enclosed drug from the environment and provides a barrier to objectionable taste or odor.

Answer 14

Sugarcoated tablets

Question 15

enhances the appearance of the compressed tablet and permits imprinting of identifying manufacturer’s information

Answer 15

Sugarcoated tablets

Question 16

Among the disadvantages to sugarcoating tablets are the time and expertise required in the coating process and the increase in size, weight, and shipping costs

Answer 16

Sugarcoated tablets

Question 17

may add 50% to the weight and bulk of the uncoated tablet

Answer 17

Sugarcoated tablets

Question 18

Compressed tablets coated with a thin layer of a polymer capable of forming a skin-like film.

Answer 18

Film-Coated tablets

Question 18

The film is usually colored and has the advantage over sugarcoatings in that it is more durable, less bulky, and less time-consuming to apply

Answer 18

Film-Coated tablets

Question 19

By its composition, the coating is designed to rupture and expose the core tablet at the desired location in the gastrointestinal tract

Answer 19

Film-Coated tablets

Question 20

facilitates swallowing, and gelatin- coated tablets are more tamper evident than unsealed capsules

Answer 20

Gelatin-coated tablets

Question 21

The innovator product, the gelcap, is a capsule-shaped compressed tablet that allows the coated product to be about one-third smaller than a capsule filled with an equivalent amount of powder

Answer 21

Gelatin-coated tablets

Question 22

Examples include Tylenol Cold Multi-Symptom Daytime

Answer 22

Gelatin-coated tablets

Question 23

Have delayed-release features

Answer 23

Enteric-coated tablets

Question 24

They are designed to pass unchanged through the stomach to the intestines, where the tablets disintegrate and allow drug dissolution and absorption and/or effect.

Answer 24

Enteric-coated tablets

Question 25

are employed when the drug substance is destroyed by gastric acid or is particularly irritating to the gastric mucosa or when bypass of the stomach substantially enhances drug absorption

Answer 25

Enteric-coated tablets

Question 26

do not dissolve in acidic condition

Answer 26

Enteric-coated tablets

Question 27

readily dissolve in alkaline ph

Answer 27

Enteric-coated tablets