introduction to drugs and pharmacy Flashcards
agent use in the diagnosis, mitigation, treatment, cure or prevention of diseases in humans or in other animals
Drug
derived from plant or animal sources, as by-products of microbial growth, or through chemical synthesis
new drugs
collective distribution of many scientific specialists, including:
organic
physical
analytical chemists
Biologic information must be gathered;
pharmacology
toxicologic features
rate of absorption and distribution
duration of action
elimination
only difference between a drug and a poison
dose
- active pharmaceutical ingredients
- responsible for the therapeutic effects in a product
Active therapeutic ingredients
nontherapeutic ingredients
pharmaceutical ingredients
instinct of an ancient man to relieve pain of a wound by:
bathing it in cool water
soothing it with a fresh leaf
protecting it with mud
believed to have connection with the world of spirits
apothecary
from greek word pharmakon
pharmacy
remedy/charm used for good or poison, a charm or a drug used for evil
pharmakon
most famous surviving artifacts
ebers papyrus
ebers papyrus is named after
Georg ebers
_____ prescription, ____ drugs
800
700
father of medicine
hippocrates
- De materia medica
- first to deal with botany
dioscorides
- greek pharmacist-physician
- aimed to create perfect system of physiology
Claudius galen
field of pharmaceutical preparations
galenic pharmacy
most famous of his formulas “galen’s cerate”
cold cream
pharmacy and chemistry became united
Emperor Frederick II
- swiss physician and chemist
- a specific medicinal agent to combat specific disease
aureolus theophrastus bombastus von hohenheim
most famous of all pharmacists
karl willhelm scheele (1742-1786)
3 discoveries of karl scheele
citric acid
lactic acid
oxalic acid
they isolated quinine and cinchonine
friedrich serturner
joseph caventou
joseph pelletier
they isolated caffeine
pelletier and pierre robiquet
he independently separated codeine from opium
pierre robiquet
organized sets of monographs or books of drug standards
pharmacopeias/formularies
comes from the greek pharmakon - drug and polein - make
pharmacopeia
must rigidly adhere to the initial standards
FDA
- wonder drug
- anti-infective
- not soluble in most common pharmaceutical solvents
- highly toxic agent used in anti-freeze solutions.
- more than 100 people died
sulfanilamide
established a legal distinction between prescription and over-the-counter or monoprescription drugs
Durham-Humphrey Amendment of 1951
- sedative and tranquilizer
- replace the barbiturates as a sedative
thalidomide
thalidomide if given during pregnancy causes:
phocomelia
highest safety-related warning
black box warnings
fails to conform to the standards
adulterated
labeling is false
misbranded
protected by the trademark
patented drug
didn’t undergo extensive clinical trials
herbs and supplements
pharmacist’s contemporary role
nuclear pharmacy
pharmacotherapy
Ambulatory care
oncology pharmacy
government service
thalidomide
kefauver-harris amendments of 1962