OINTMENTS, CREAMS AND GELS I Flashcards
containing one or more medicinal agents dissolved or dispersed in either
semisolid preparations
water-in-oil (W/O) emulsion
cold cream
oil-in-water (O/W) emulsion
vanishing cream
PREPARATION OF CREAMS May be formulated from:
- Oils – mineral and vegetable oil
- Fatty alcohols
- Fatty acids
- Fatty esters
water-insoluble components
Lipid
water-soluble components
aqueous
sometimes called “jellies”
gels
Examples of gelling agents:
synthetic macromolecules
cellulose derivatives
natural gums
Carbomers
carbomer 934
synthetic macromolecules
carboxymethylcellulose
cellulose derivatives
tragacanth.
natural gums
high molecular weight water-soluble polymers of acrylic acid
Carbomers
yields highest viscosity
940
gel mass consisting of floccules
Two-phase gel
macromolecules are uniformly distributed
single-phase gels
Penetration enhancers include
ethanol
urea
PEG
glycerin
Tweens
small distinct particles often referred to as a
magma
Gels may thicken on standing, forming a _______
thixotrope
deliver the drug into the skin
topical dermatological
deliver drugs through the skin
transdermal