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t5drugs Flashcards

antibacterial, antidepressants

1
Q

Penicilloic acid

A

one of the breakdown products of penicillin that can cause an hypersensitivity rxn

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2
Q

how to tx pseudomonas

A

1. anti-pseudomonas penicillins: ticracillin and piperacillin

3rd gen cepholosonin(zone and dime),

4th gen cepholosporin

Carbapenems(except Etrapenem)

Monobactam/ Aztronam

amino glycoside

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3
Q

tx febrile neutropenia

A

anti-pseudomonas penicillins: ticracillin and piperacillin

Cefipime - 4th gen cepholosporins

Chloramphenicol

anything broad spectrum will work

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4
Q

MRSA tx

A

5th gen - ceftraroline

Vancomycin(DOC)
Daptomycin

tetracyclines

clindamycin

linezolid

mupirocin

rifampin

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5
Q

can be given by inhalation to CF patiences

A

aztronam for pseudomonas

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6
Q

binds D-ala D-ala

A

vancomycin

becomes resistant is D-ala changes to D-lactate

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7
Q

empiric
treatment of infective endocarditis

what if the person has a valve replacement

what is there is resistance to the first line

A

Vanco and gent

if there is a valve replacement add rifampin

if there is resistance to vanco try daptomycin / linezolid

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8
Q

tx c.diff

A

Vanco (oral!)
Fidaxomicin
Metronidazole

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9
Q

what is daptomycin off limits for (2)

A

pneumonia

also do not give with statins bc both elevate creatine phosphokinase/ causes muscle pain.

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10
Q

Binds to cell membrane via calcium-dependent insertion
of lipid tail, results in

A

daptomycin

Results in depolarization of cell membrane with K+ efflux
→ cell death

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11
Q

Bind reversibly to 30S subunit of ribosome, preventing….

A

tetracyclines

preventing attachment of aminoacyl tRNA

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12
Q

drug that can target intracellular orgs

what else does this drug cover

list then

A

tetracycline
and covers atypical

listeria, Rocky Mountain, chlamydia/neisseria, mycoplasma

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13
Q

intracellular orgs
10

A

listeria, Neisseria, herpes, toxplasmosis, chlamydia, mycoplasma tuberculosis, rickettsia, leishmania, brucella-parasite

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14
Q

common tetracycline resistnace

A

increased efflux pump

inference with binding of ribosomes.

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15
Q

severe acne & rosacea

A

tetracycline

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16
Q

emperic therapy of outpatient community acquired pneumonia

outpatient with comorbidities

A

doxycycline

or

macrolide

if comorbidities: rest fluoroquinolone or macrolide plus beta lactam

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17
Q

treating atypical pneumonia
examples?

A

tetracyclines
macrolides(DOC)

Mycoplasma,
Chlamydia, Legionella

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18
Q

syphillus tx if allergic to peniclinnin

A

tetracycline

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19
Q

tetracyclin
Drugs of choice for:

Used in combination for:
* H.pylori eradication
* Malaria prophylaxis and treatment
* Treatment of plague, tularemia, brucellosis

A
  • *Chlamydia
  • *Mycoplasma pneumoniae
  • Lyme disease
  • Cholera
  • Anthrax prophylaxis
  • Rickettsia (Rocky Mountain Spotted Fever,
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20
Q

dont take with calcium

A

tetracycline
floroquinolones

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21
Q

tetracyclines AE

A

discoloration of teeth, growth stunt(dont give in pregnancy and under 8yo)

fatal hepatotoxicity

accumulation in many organs including skin causing photosensitivity

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22
Q

concentration dependent killing

A

aminoglycosides
one dose a day is more efficious

all the other drugs are time dependent killing

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23
Q

30S ribosomal subunit prior to
ribosome formation leading to irreversible inhibition of
initiation complex :
* misreading of mRNA, &
* blockade of translocation

A

amino glycoside

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24
Q

aminoglycoside resistance

A

synthesis of enzymes that
modify and inactivate drug by acetylation,
phosphorylation and adenylation

issue with 30s

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25
Q

Empiric therapy of serious infections eg, septicemia,
nocosomial respiratory tract infections, complicated
UTI’s, endocarditis etc

A

aminoglycosides

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26
Q

Neomycin for

A

bowel surgery prep and hepatic
encephalopathy, as well as topically

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27
Q

gonorhea

first line
2nd line
if resistant

A
  1. ceftriaxone
  2. aztronam

Gentamicin + azithromycin

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28
Q

high levels of amino glycoside in

A

renal coretx and inner ear

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29
Q

amino glycoside AE

A

time and concentration dependent(can accumulate in blood)

ototoxicity, nephrotoxicity, NM blockade, contraindicated in pregnancy bc can cause tubular necrosis

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30
Q

hepatic encephalopathy

A

neomycin, lactulose, oral vanco, oral metro, rafiximin

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31
Q

reduce
plasma ammonia concentrations

A

laculose

also acts as a factitive

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32
Q

Reversibly bind to the 23S rRNA of the 50S subunit
blocking…

A

macrolides

blocking translocation

Binding site is identical or close to that for clindamycin & chloramphenicol
-chloramphenicol blocks peptidyltransferase
-clindamycin blocks translocation

streptogramins also bind here

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33
Q

macrolides resistance

A

Production of esterase that hydrolyze drugs

modification of ribosomal binding site

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34
Q

emperic therapy of inpatient community acquired pneumonia

A

macrolide + beta lactam

3/4th gen floroquinolone

(can mix up all three)

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35
Q

DOC for whooping cough (B.pertussis)

A

erythromycin

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36
Q

CYP P450 inhibition

A

macrolides: E and C

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37
Q

macrolides AE

A

hepatic
QT prolongation
GI upset(give fluids)

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38
Q

which antibiotics have contraindications with statins

A

macrolides (bc inhibits CYP 450)
daptomycin(both elevate CPK)

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39
Q

babesiosis tx

A

macrolides

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40
Q

life threatening with no alternatives

A

chloramphenicol
glycyclin
cifipem
streptogratins(G+)

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41
Q

Can inhibit protein synthesis in mitochondrial ribosomes

result?

A

chloramphenicol

bone marrow toxicity- irreversible aplastic anemia

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42
Q

Inhibits hepatic oxidases (3A4 & 2C9)

A

chloramphenicol

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43
Q

chloramphenicol AE

A

bone marrow toxicity
grey baby syndrome

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44
Q

ricketsia

A

chloramphenicol

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45
Q

causes C diff

A

clindamycin
amp/amoxicillin
cepholosporins
fluoroquinolone

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46
Q

PCP tx

A

co-trimethoprim
or
clindamycin + primaquine

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47
Q

toxoplasmosis tx

A

cotrimoxazole + pyrimethamine
or
clindamycin + pyrimethamine

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48
Q

Binds to unique site on 23S ribosomal RNA of 50S
subunit causing…

A

linezolid

causing inhibition of 70s complex formation

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49
Q

linezolid ae

A

long term
bone marrow suppression/ thrombocytopenia

optic neuropathy
peripheral neuropathy

serotonin syndrom if also taking MAO I

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50
Q

Block protein synth by binding RNA polymerase

providing coverage against…

A

fidaxomicin

covers G+ aerobes and anaerobes

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51
Q

Fidaxomicin AE

A

GI

approved for all bactrove 6 mo

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52
Q

Only topical/intranasal agent with activity against
MRSA

A

mupirocin

only treats staph and strep

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53
Q

Binds to bacterial isoleucyl transfer-RNA synthetase
resulting in the inhibition of protein synthesis

A

mupirocin

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54
Q

meningitis prophylaxis

A

Cefriaxone
Rifampin
Ciprofloxacin

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55
Q

tx travelers diahrea

first choice and alt

A

ciprofloxacin

or
amoxicillin

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56
Q

levofloxacin can tx

A

community acquired pneumonia / walking pneumonia
STDs(not syphillus)
URTI
TB

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57
Q

emperic tx for pylonephritis

A

floroquinolone

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58
Q

fluoroquinolone ae

A

CT snapping
peripheral neuropathy
QT prolongation
superinfections
not for children less than 18

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59
Q

Structural analogs of p-aminobenzoic acid (PABA) which will….

A

sulfonamides

which will inhibit the production of folic acid bc it is a competitive inhibitor to dihydrohopterate synthase

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60
Q

sulfonamides uses

A

topically for ocular or burns ir orally for UTI

coveras G- and G+

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61
Q

sulfonamides AE

A

nephrotoxicity - crystaluria

in pts with G6PD causes haemapoetic disturbances

kernicterus

takes other drugs off albumin, so will fuck up warfarin/ phenytoin

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62
Q

Structurally similar to folic acid which will inhibit….

A

trimethoprime

which will inhibit dihydrofolate reductase

*antifolate products are contraindicated in pregnancy

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63
Q

trimethoprime uses

A

UTI
prostatitis
vagninitis

reaches high concentrations in the urine and prostatic fluids

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64
Q

cotrimoxazole uses

A

DOC UTI
DOC PCP
DOC norcardia
toxo, UTRI

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65
Q

cotrimoxazole AE

A

pancytopenia/hemolytic anemia
renal tubular acidosis in babies

contraindicated in pregnancy for kernicterus, albumin problem and other sulfa AE

cyp450 inhibitor

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66
Q

Undergoes reductive bioactivation of its nitro group by
ferredoxin. Forms cytotoxic products that interfere with nucleic acid
synthesis

A

metronidazole

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67
Q

Blocks transcription by binding to b subunit of bacterial
DNA-dependent RNA polymerase leading to…

A

inhibition of RNA synthasis

rifampin

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68
Q

rifampin uses

A

mycobacteria…TB!
MRSA
G+ and G-(Hib prophylacis)
prophylaxis meningitis

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69
Q

rifampin resistance

A

rpoB mutation in RNA polymerase

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70
Q

Hib prophylaxis

A

rifampin

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71
Q

cyp 450 inducers

A

rifampin

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72
Q

rifampin AE

A

organe fluids
light chain proteinuria
SAFE IN PREG
hepatotoxic

73
Q

PolymyxinB coverage

A

polymyxin B

only used as topical for G- but if systemic extremely nephrotoxic

via cationic detergent

74
Q

Reduction of drug by bacteria in the urine leads
to formation of reactive intermediates that subsequently
damage bacterial DNA

A

nitrofurantoin

75
Q

prophylaxis for infective endocarditis

if allergic mild/severe

if cant take oral pills

A

amoxicillin
if mild allergic: cepholexin
if severe allergic: clindamycin, macrolide,
if cant take oral meds: ampicillin/clinda

(not just dental procedure but any invasive respiratory tract procedure)

75
Q

nitrofusomide contraindications

A

renal insufficiency
at term of pregnancy
infants have risk of hemolytic anemia

76
Q

gun shot anitbiotics
if allergic

A

carbapenem
if allergic
vancomycin + gentimycin

77
Q

sx and tx:
-klebsiella pneum
-legionella pneumo
-mycoplasma pneu
-maxorella
-aspirational pneum
-chlamydia pneumo

A

Klebsiella-“jelly sputum” and causes lobar pneumo G-: 1.ceftriaxone, 2.fluoro

Legionella-MSI inc GI and confusion, need iron and cysteine for culture: 1. fluoro/macrolide 2. tetracycline

mycoplasma- dry cough and low fever 1. macrolide, tetracycline 3. fluoro

maxorella: like most UTRI, amoxicillin, co-trimoxizole, cepholosprins

aspirational/anaerobic = clindamycin

chlamydia-obligate intracellular =1.doxycycline 2. macrolide/ fluoro

78
Q

emperic STD tx

A

ceftriaxone and doxycycline

79
Q

chlamydia tx
first line
if resistantr

what is a confirmatory test

A

doxycycline

azithromycin OR levofloxacin

diagnosed with NAAT

80
Q

infective endocarditis caused by alpha hemolytic strep viridian
3

A

penicillin/ampicillin
vancomycin
ceftriaxone

for some reason they suggest option to add gentimycin

81
Q

staph aureus infective endocarditis tx

A

anti-staph beta lactams
if mild allergy: cefazolin
if severe: vancomycin

for some reason they suggest the option to add gentimycin

82
Q

GAS pharyngitis but allergic to penicillins

A

macrolide
clindamycin
cotrimoxazole

goes for most URTI

83
Q

tularemia tx

first line and back up

A

streptomycin

chloramphenicol

84
Q

giardia presentation and tx

A

tx: metronidazole
GI protozoa

85
Q

UTI tx first line and other options

what if pregnant

A

co-trimoxazole

nitrofuscion
cipro
amoxicillin

if pregnant:
penicillins, cepholosporins, nitrofucion/sulfonamides but not if past 38 weeks/end of term

86
Q

prostatits tx

A

fluoroquinolone
co-trimoxazole
doxy

87
Q

emperic meningitis

A

vancomycin + ceftriaxone

88
Q

MAC treatment and prophylaxis

A

macrolide, ethanbutol, rifabutin

prophylaxis is macrolide

89
Q

virus life cycle

blocked with:
neuramidase inhibitors, endonuclease inhibitors, guanosine analogue, nucleoside/tide analogue, NS inhibitors, purine/pyrimidine analogue

A

binding, uncoating, gene replication, iron assembly, maturation, release

Neuramidase inhibitors block release

endonuclease inhibiors, guanosine analogue, ATP analogue, neucleoside/tide analogue, NS inhibitors, and purine/ pyrimidine analogue(only on actively replicating) block gene replication

for HIV it is binding, fusion/entry, unceasing, reverse transcriptase, integration, transcript, assembly, maturation, release

90
Q

neuramidase binds

A

sailiac acid R

so cant be cleaved from host

91
Q

Prophylaxis and treatment of Influenza A and B

acute uncomplicated

A

Neuramidase Inhibitors
1. Oseltamivir(oral)
Permavir (parenteral)
Zanamavir(nasal)

endonuclease inhibitor- if 12 or older

both have to be less than 48 hrs

92
Q

Neuramidase Inhibitor AE

A

Oselatamivir: Gi upset, eat with food.

Zanamavir: airway irritation avoid in asthma and CPOD

Pernavir:itchy, peeling skin

93
Q

Endonuclease inihbitor AE

A

diahreah and bronchitis

94
Q

polymerase acidic
(PA) protein

A

required for coral gene replication and blocked by endonuclease inhibitor

95
Q

Inhibits RNA-dependent RNA polymerase

A

guanosine analogue:
ribavirin
(another guanosine analogue is abacavir)
-inhibits by inhibiting guanosine triphosphate formation so can do mRNA capping

ATP analogue: Remdesivir
-evades proofreading by viral exoribonuclease EXoN

Both cause dec in viral RNA production

NS5B: Sofobuvir.

96
Q

prevents viral mRNA capping

A

ribaviran

97
Q

Influenza A & B, Parainfluenza, RSV, HCV,

A

ribaviran

98
Q

ribaviran AE

A

prolonged distribution into RBCs and can cause hemolytic anemia causing JAUNDICE

and is pregnany X

99
Q

COIVD 19 tx

A

remdesivir

100
Q

remdesivir AE

A

Respiratory failure*, hypokalemia, hypoalbuminemia,
neutropenia, jaundice

101
Q

indirectly inhibit RNA & DNA synthesis by inducing protein expression that inhibit virus infection
(PKR)

A

interferons

102
Q

what are the different interferons used for

A

alpha: for CHRONIC Hep b + entecavit and for Hep C+ ribaviran, condyloma acuminata(HPV-NE dsDNA), hairy cell leukemia, Kaposi sarcoma(HHV8), melanoma

beta: multiple sclerosis

gamma:l chronic granulomatous disease

103
Q

interferon AE

A

flu sx, neutropenia esp when with zidovudine(HIV)/ myelosupression

can cause liver failure if given in acute HBV

104
Q

Usually pegylated to improve PK profile

A

interferon alpha

105
Q

suppressive for Hep B

A

interferon alpha and nucleotide/side inhibitors

106
Q

Triphosphate form (active) needs to be phosphorylated

A

Lamivudine, Adefovir, Tenofovir, Entecavir (nucleoside/tide analouges)
-which will supress HBV and HIV reverse transcriptase

all drugs with cycle/ciclo
-to be activated by viral thymidine kinase and host kinases…cidofovir and trifluridine only need to be phosphorylated by the host kinases

NRTIs [hosphorlated by host

107
Q

Hepatitis B and HIV

A

Lamivudine. If you want to treat HBV give a low dose less frequent. can also prevent the vertical transmission if given in the last 4 weeks

Entecavir for lamivudine resistant HBV/HIV and just preferred for acute and chronic

108
Q

-previr

A

N3/N4a inhibitor for Hep C

109
Q

Bind reversibly to nonstructural serine protease
and inhibit replication of HCV / distruction

A

sim glec tela

previr

use if INFa + ribavirin did not work or also if never treated

if treating chronic HCV + Ledipasvir

110
Q

N3/4a AE

A

severe itching, rash, photosensitivity, Stevens-Johnson
syndrome (rare)

111
Q

Inhibits viral phosphoprotein, which is necessary for viral
replication, assembly, and secretion of HCV

A

NS5a, LEDIPASVIR

112
Q

LEDIPASVIR AE

A

headache, diahrea

113
Q

DNA polymerase inhibitor and DNA chain terminator

A

acyclovir/v
ganciclovir/v
cidofovir
penciclovir

114
Q

HSV types 1 and 2, VZV & some Epstein-Barr (HSV4)

A

acyclovir

NOT CMV bc that bug doesn’t code thymidine kinase

115
Q

*DOC for HSV encephalitis

A

-temporal leison
acyclovir

116
Q

IC herpes prophylaxis and treatment for normal general herpes

A

acyclovir

117
Q

RESISTANCE is due to:
* Altered or deficient thymidine kinases
*Altered viral DNA polymerase with decreased affinity for
acyclovir

A

acyclovir

118
Q

why give vancyclovir less often

A

prodrug of acyclovir so have greater oral bioavailability. will partially metabolize causing accumulation in kidneys (even if giving acyclovir IV)

119
Q

obstructive crystalline nephropathy

how to prevetn

A

IV acyclovir

hydrate the pt and infuse slowly

120
Q

CMV infection (retinitis, esophagitis, colitis etc.) & CMV
prophylaxis in immunocompromised

A

Gancyclovir/valgalcyclovir

121
Q

RESISTANCE is due to:
* Reduced intracellular phosphorylation
* UL97 or viral DNA polymerase mutations

A

ganciclovir

122
Q

Gancyclovir AE

A

myelosupression and neutropenia

123
Q

Ganciclovir resistant HSV

A

cidofovir

also for Used for CMV retinitis in HIV-AIDS patients

124
Q
  • NOT phosphorylated by viral kinases
  • Requires activation by host cell kinases
A

cidofovir

125
Q

cidofovir AE

A

nephrotoxicity , needs to be paired with probenecid(blocks tubular secretion of the drug)

126
Q

Active against HSV-1, HSV-2 and VZV

  • Used for topical treatment of HSV (cold sores): poor oral
    absorption
A

pencyclovir

127
Q

DOC for HSV keratoconjunctivitis and recurrent epithelial keratitis

Active against HSV-1, HSV-2 and vaccinia virus

A

TRIFLURIDINE

given as ophthalmic ointment only

128
Q

Selectively inhibits the pyrophosphate binding site on viral DNA polymerases

A

foscarnet

doesn’t require phosphorylation

129
Q

Binds specifically and selectively to CCR5 which blocks

A

blocks fusion and entry

MARAVIROC

130
Q

Structurally similar to gp41

A

enfuvirtide

will inhibit fusion

131
Q

Lack of 3’OH terminates DNA elongation

A

NRTIs

HIV

132
Q

NRTIs AE

A

lactic acidosis
peripheral neuropat (bc inhibiton of DNA poly)
Zidovudine and stavudine = dyslipidemia

133
Q

thymidine anlouge

A

stavudine
Zidovudine

134
Q

Strong inhibitor of beta and gamma DNA polymerases (high affinity for mitochondrial DNA
polymerase, which can lead to toxicity)

A

stavudine, didamosine

s++peripheral neuropahty, lactic acidosis, hyperlipidemia, weakness, pancreatitis

d++pancreatitis, peripheral neuropath, hepatic dysfunction DO NOT GIVE

135
Q

adenosine analouge

A

tenofovir
the only nucleotide

didanosine

136
Q

tenofovir AE

A

can cause GI upset in lactose intolerant ppl

must monitor creatine levels

137
Q

tenofovir + didenoaine / +atazanavir

A

inc concentrations didanosine

dec concentration of atazanavir and will need to add ritonavir

138
Q

one of the recommended ARVs for pregnancy, labor,
postpartum and post-exposure prophylaxis of infants. used for LOW risk infants(mom was taking her meds)
*Significant reduction in vertical transmission of HIV

A

zidovudine

139
Q

zidovudine AE

A

MACROCYTIC anemia
neutropenia

dont give with stavudine

140
Q

cytosine analoude

A

lamivudine
emtricitabine

141
Q

DOES NOT affect mitochondrial DNA synthesis or bone marrow
precursor cells

A

LAMIVUDINE

142
Q

High level resistance occurs with single amino acid substitutions

A

LAMIVUDINE

143
Q

Hyperpigmentation of palms and soles

A

emtricitabine

144
Q

Contraindicated if patient has HLA-B*5701 mutation.

A

abacaivir

can cause type 4 delay hypersensitivity rxn

145
Q

Noncompetitive inhibitors of
REVERSE
TRANSCRIPTASE

A

RILPIVIRINE
EFAVIRENZ
NEVIRAPINE

146
Q

inhibition of RNA & DNA-dependent DNA polymerase

A

NNRTIs

147
Q

*Used for HIV-1 ONLY

A

NNRTIs
better because there is less likely to have attack on blood tissues

148
Q

NNRTI AE

A

skin irritation SJS
=tissue necrosis
they fuck with CYP

149
Q

One of the NNRTIs recommended for use in pregnancy

A

Rilpivirine

150
Q

Rilpivirine AE

A

QT prolongation, elevated LFT, elevated creatine

151
Q

HIV drug High rate (50%) of CNS toxicities (dizziness, drowsiness, insomnia,
nightmares, vivid dreams, headaches)
Psychiatric disturbances (depression, mania, psychosis)
possible association with suicidality

A

efavirenz

also teratogenic
and need to monitory lipid levels

152
Q

Nevidapine AE

A

severe hepatotoxicity and should not be used in women with +250 or in men +400

153
Q

Its only current use is for post-exposure prophylaxis of high-
risk infants born to HIV-infected mothers

A

Nevidapine

154
Q

-tegravir

A

integrase inhibitors

155
Q

GI upset, rash, elevated CPK,
rhabdomyolysis

A

Raltegravir and Dolutegravir

156
Q

-navir

A

protease inhibitors

157
Q

reversible inhibition of HIV aspartyl proteases

A

protease inhibitors

which will block maturation so the viron that is released is non infectious

158
Q

Resistance is due to
accumulation of stepwise
mutations

A

protease inhibitors

159
Q

which protease inhibitors are particularly affected by high fat meals

A

inc availability in nelfavir

dec availability in indinavir

160
Q
  • Disturbances in lipid metabolism (hypertriglyceridemia,
    hypercholesterolemia & diabetes)
A

protease inhibitors

get Cushing type

except atazanavir

161
Q

which protease inhibitor can not be boosted by ritonovir

A

nelfinavir

162
Q

PK enhancers block

A

CYP 3A4

163
Q

*Used commonly in combination
with the INSTI elvitegravir
*Also found in combination with
darunavir and atazanavir

A

COBICISTAT

164
Q

*Used in combination with
most protease inhibitors but
not nelfinavir

A

ritonavir

165
Q

HIV prophylaxis

A

EMTRICITABINE
+
TENOFOVIR

166
Q

HIV post exposure prophylaxis

A

EMTRICITABINE
+
TENOFOVIR
+
Dolutegravir/Raltegravir

give for 28 days

167
Q

HIV treatment naive reginem

A

tenofovir + emtricitabine +Dolutegravir/ Raltegravir/ Bictegravir

abacavir + lamivudine + Dolutegravir

168
Q

cold agglutination tests for what orgs

A

mycoplasma pneumo
EBV
CMV
Legionella

169
Q

daptomycin AE

A

muscle pain, interstitial fibrosis

170
Q

amoxicillin resistance reason vs amoxicillin-clav resistance

A
  1. increased enzymatic destruction of antibiotic
  2. modification of PBPs
171
Q

monitoring for herpes drugs

A

acyclovir need CBC, renal, and liver

gancyclovir: CBC, renal

cidofovir : renal

forscanet: renal. electrolytes

172
Q

Physical examination shows a somnolent
man with conjunctival icterus, ascites, and 2+ edema of the lower extremities.
Cranial nerves are intact. Muscle strength is 4/5 throughout. When he is awake,
there is a postural and action tremor of the forearms and hands that is
accompanied by a sudden, brief loss of muscle strength. His speech is normal,
and he can follow simple commands

A

hepatic encephalitus

173
Q

condylomata lata, a maculopapular rash involving the palms and soles, and patchy alopecia

A

secondary ssyphillus

174
Q

bactracin

A

topical use
antibiotic works as cell wall inhibitor

175
Q

inhibited by antacids

A

tetracycline
antifungals

176
Q

intracellular orgs

A

bacteria: ricketsia, chlamydia, neissera, listeria, mycoplasma

parasite: brucella, toxo, leishmania

virus: herpes

177
Q

-pristin

A

streptogramin

term 4 (13 decks)

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