T4 - Hypertensive Disease (Josh) Flashcards
— disorders are the most common medical complication of pregnancy.
Hypertensive
***risen steadily since 1990 in all races and ethnic groups
What are some potentially lethal complications from Hypertensive Disorders?
Pre-eclampsia
Abruptio Placentae
DIC
Acute Renal Failure
Hepatic Failure
Adult Respiratory Distress Syndrome (ARDS)
Cerebral Hemorrhage
HELLP Syndrome
How HTN defined in pregnancy?
140/90 or more on at least 2 separate occasions 4-6 hrs apart within a maximum of 1 wk
***sitting, no tobacco/caffeine 30 mins prior
What is Gestational HTN?
onset of HTN without proteinurea after 20 wks gestation
— usually occurs 20 weeks after gestation in a previously normotensive patient AND has proteinurea.
Preeclampsia
What proteinurea is a sign of preeclampsia?
above 30 mg (1+ on dipstick) or more in 2 random specimens at least 6 hrs apart
or
300 mg in 24 hrs
What is difference b/t Preeclampsia and Eclampsia?
seizures
What is HTN that occurs before pregnancy or diagnosed before 20th week gestation?
Chronic HTN
***persists more than 6-12 wks PP
What is Preeclampsia superimposed on Chronic HTN?
Chronic HTN patient w/ new proteinurea or an exacerbation of HTN or Proteinurea, thrombocytopenia, or increase in hepatocellular enzymes
What BP is HTN?
What MAP is HTN?
140/90
MAP > 105
Are BP elevations over pre-pregnancy values diagnostic for preeclampsia?
No
but women with an increase of 30 (systolic) or 15 (diastolic) warrant further watching when they have proteinurea and hyperuricemia (uric acid of 6 or more)
What has to be elevated for it to meet the definition of Gestational HTN?
either systolic or diastolic
only one is needed to be elevated for it be diagnostic
What percentage of Primigravidas have Gestational HTN?
Multiparous?
Primigravidas = 6-17%
Multiparas = 2-4%
Gestational HTN is more frequent in — pregnancies.
multifetal
When does Gestational HTN normally develop?
at or after 37 weeks if they have no preexisting HTN
***BP returns to normal within 1-12 wks after delivery
What is Mild Preeclampsia?
140/90
MAP > 105
24 hr proteinurea > or = 0.3 g
What is Severe Preeclampsia?
160/110
Map > 105
24 hr proteinurea > 2 g
What is usually the first sign of preeclampsia?
elevated BP
— occurs in too many normal pregnancies to be used as a marker for preeclampsia.
Edema
What is the only cure for preeclampsia?
delivery
What weight gain is a sign of preeclampsia?
> 2 kg (4.4 lb) in one week
What is the etiology of preeclampsia?
disruption of placental perfusions and endothelial cell dysfunction
What is the cause of preeclampsia?
uknown
Preeclampsia:
What do disruption of placental perfusions and endothelial cell dysfunctions lead to?
Vasospasm
Increased Peripheral Resistence
Increased Endothelial Cell Permeability
***all leading to decreased tissue perfusion
T/F: The major pathological factor in preeclampsia is elevated BP.
False
it is poor perfusion as a result of vasospasm
Preeclampsia:
What drug do we give?
Mag Sulfate
4-6 g loading dose then a 2-3 g maintenance dose
***have a fan b/c they’ll be hot