T1Q6 Cancer 1 Flashcards
oncogene
a dominantly acting ene that can contribute to cancer
tumor supressor gene
?
gate keeper
?
contact inhibition
cells normally enter a quiescent G0 phase when fully in contact with one another
anchorage independent growth
normal cells have difficulty growing in suspension without an attachment to an extracellular mesh
proto-oncogene
a normal gene that can become an oncogene through mutation that cause:
- over-expression
- constitutively active protein
acutely transforming retroviruses
defective viruses that encode an oncogene
slow transforming retroviruses
replication competent viruses that activate a cellular proto-oncogene through insertional mutagenesis.
EGF
epidermal growth factor
Her2
a transmembrane receptor that forms hetero and homo dimers that depends on the EGFR
v-erB
a transmembrane receptor that forms a heterodimer with Her2
process: oncogene activation by retroviral infection
?
Ras
wh: proto-oncogene, a small GTP binding protein
sign: anything that causes Ras to remain bound to GTP and active make it oncogenic
Raf
wh: a protein kinase with an autoinhibitory domain
sign: mutations the inhibitory domain cause it to become constitutively active
Her2 and v-ERB
?
