Cancer 3 Flashcards
1
Q
Mechanisms of oncogene activation
A
?
2
Q
reciprocal translocation
A
exchange of large chunks of DNA
- fusion of one enhancer to coding sequence of another gene= inappropriate expression of a normal protein
- fusion of exons to form a “chimeric protein”
3
Q
inversion
A
?
4
Q
philadelphia chromosome
A
a translocaiton chromosome characteristic of myelogenous leukemias
5
Q
BCR
A
break point cluster region
identified by localization of breakpoints that form the philadelphia chromsome and subsequently create crimeric proteins
6
Q
ABL
A
transmembrane protein that is activated by intracellular proteins
7
Q
BCR/ ABL chimeric protein
A
the fusion protein removes autoinhibition and it is no longer spatially restricted to the membrane
