T-LGL Flashcards
1
Q
Phenotype
A
CD3+, CD8+, CD57+, CD56-, CD28-, TCR-ąß+
Uncommonly- CD4+
10% have TCR-ɣ∆ with better prognosis
2
Q
Clinical menifistations
A
Usually indolent course:
Anemia
Neutropenia
Splenomegaly
RA
3
Q
Indications for treatment
A
Transfusion dependence/Symptomatic anemia
ANC< 500
ANC > 500 with recurrent infections
RA
4
Q
Treatment options
A
Low dose MTX
Cyclophosphamide- 9-12 months
Cyclosporin A- 2nd line
5
Q
Definition of CR
A
ANC> 500
Hb>12
PLT> 150
Lymphocyte< 4K
Normal range of LGL in PB
6
Q
Definition of PR
A
Improvement in blood counts w/o CR
7
Q
Clinical failure
A
Absence of PR/CR after 4 months of Tx
8
Q
Salvage therapies
A
Purine analogs
Alemtuzumab (anti-CD52)
