PCNSL Flashcards
1
Q
Evaluation
A
Brain MRI Ophthalmologic evaluation LP BM PET-CT HIV
2
Q
Prognostic scores
A
IELSG
MSKCC
3
Q
IELSG
A
Age ECOG LDH CSF protein Deep brain involvement
4
Q
MSKCC
A
Age
Karnofsky perfoemance status
5
Q
Ferreri et al
A
Addition of cytarabine to WBRT and HD-MTX resulted in better OS
6
Q
MATRix
A
Addition or Rituximab prolonged PFS
7
Q
DeAngelis
A
HD-MTX with addition of Procarbazine Vincristine Rituximab
followed by reduced dose (23.4 Gy) WBRT
8
Q
Intrathecal
A
Not used
No ORR or OS benefit
9
Q
Relapse rate
A
50%
10
Q
Primary refractory disease
A
10-15%
11
Q
Median tome to relapse
A
10-18 months
