Thrombocytosis

Question 1

Reactive causes

Answer 1

IDA
Bleeding
Infectious, melignant (solid), inflammatory
Post-splenectomy

Question 2

Hematologic causes

Answer 2

MPN
CML
MDS del(5q)
AML

Question 3

Causes- groups

Answer 3

Reactive
Autonomous (Hematologic)
Familial

Question 4

When to check for MPN

Answer 4

Vasomotor or constitutional symptoms
Splenomegaly
Unusual thrombotic presentation

Question 5

Initial evaluation

Answer 5

CBC + blood smear
Iron studies
ESR + CRP if suspected infalmmatory/infectious
MPN w/u if suepected