CMML Flashcards
1
Q
Median age
A
72
2
Q
M:F
A
2.3:1
3
Q
Blood count
A
> 10% of WBC
1K
for 3 months
4
Q
Heatologic diseases to exclude
A
PV, ET, PMF, CML
AML
If eosinophilia present r/o PDGFRa PDGFRb FGFR1 - PCR + FISH
5
Q
Cytogenetic abnormalities
A
Trisomy 8 Loss of Y Monosomy 7 del 7p Trisomy 21 del 20q
6
Q
Mutations
A
TET2 and SRSF2- most important
ASXL1
RAS (NRAS, KRAS, CBL)
7
Q
Workup
A
Diseases to exclude
Flow cytometry for monocyte subsets
BMB
8
Q
Flow cytometry
A
(CD14+ CD16-) cells > 94%
