FL Flashcards

1
Q

Median age at diagnosis

A

65 years

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2
Q

M:F

A

1:1

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3
Q

B symptoms %

A

20%

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4
Q

increased LDH %

A

25%

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5
Q

Duodenal-type follicular lymphomas

A

Uusually 2nd part

Same Tx as nodal FL

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6
Q

Immunophenotype

A

CD21
CD23
CD35
IgM IgdD +/- IA

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7
Q

Grade

A
Centrblast/high power field
I: 0-5
II: 6-15
IIIA> 15 with centrocyte present
IIIB > 15 no centrocyte
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8
Q

Translocations

A

t(14:18) 85% IGH:BCL2
t(2:18) Uncommon Kappa: BCL2
t (18:22) Uncommon Lamda:BCL2

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9
Q

FLIPI

A
Age >60
Stage III / IV 
Hbl <12
Involved nodal areas >4 
LDH ↑
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10
Q

FLIPI risk

A

High 3-4 –PFS 42 months, two-year OS 87 percent

Intermediate 2 – PFS 70 months, two-year OS 94 percent

Low 0-1– PFS 84 months, two-year OS 98 percent

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