FL Flashcards
1
Q
Median age at diagnosis
A
65 years
2
Q
M:F
A
1:1
3
Q
B symptoms %
A
20%
4
Q
increased LDH %
A
25%
5
Q
Duodenal-type follicular lymphomas
A
Uusually 2nd part
Same Tx as nodal FL
6
Q
Immunophenotype
A
CD21
CD23
CD35
IgM IgdD +/- IA
7
Q
Grade
A
Centrblast/high power field I: 0-5 II: 6-15 IIIA> 15 with centrocyte present IIIB > 15 no centrocyte
8
Q
Translocations
A
t(14:18) 85% IGH:BCL2
t(2:18) Uncommon Kappa: BCL2
t (18:22) Uncommon Lamda:BCL2
9
Q
FLIPI
A
Age >60 Stage III / IV Hbl <12 Involved nodal areas >4 LDH ↑
10
Q
FLIPI risk
A
High 3-4 –PFS 42 months, two-year OS 87 percent
Intermediate 2 – PFS 70 months, two-year OS 94 percent
Low 0-1– PFS 84 months, two-year OS 98 percent