T cell responses to HIV

Question 1

Evidence for the role of CD8 cells in the control of HIV-1 replication

Answer 1

• found in large numbers in HIV-infected humans
• can inhibit HIV replication in vitro
• partial control during early infection correlates temporally with emergence of HIV-specific CTL
• in monkeys, in vivo depletion of CD8 T cells by infusion of monoclonal antibodies to CD8 have profound effects on the replication of SIV

Question 2

Mechanisms used by CD8 CTL to control HIV infection

Answer 2

• can kill HIV-infected cells with perforin and granzymes
• can produce soluble factors that are anti-viral/activate APCs
• B chemokines have activity against HIV
• all HLA restricted activities

Question 3

HLA alleles associated with long term non-progression

Answer 3

HLA-B57
HLA-B27
HLA-B51

Question 4

HLA alleles associated with rapid progression

Answer 4

HLA-B35