HIV Cure Flashcards
1
Q
Types of cure
A
- sterilizing
- functional
2
Q
What is a major barrier to HIV cure?
A
The latent viral reservoir
3
Q
How is the reservoir established?
A
- resting memory cells are created
4
Q
Types of HIV latency
A
- pre-integration
- post-integration
5
Q
Describe pre-integration latency
A
- inhibition of reverse transcription or transport of integration complex to nucleus due to reduced dNTPs and ATP in inactive cells
- host restriction inhibits transcription
- not stable
6
Q
Describe post-integration latency
A
- silencing after integration
- transcription prevented interference (steric hinderance by RNA polymerase 2)
- very stable
7
Q
How to measure the reservoir
A
- viral outgrowth assay (VOA)
- PCR
8
Q
How does the reservoir persist?
A
- stability
- homeostatic proliferation (clonal expansion)
- low-penetrance sancturies
- low-level reactivation of latent cells
9
Q
Possible cure strategies
A
HDAC inhibitions in combo with: - Abs - T-cells - ARV treatment - therapeutic vaccines Gene therapy
