HIV Treatment Strategies Flashcards
1
Q
Examples of entry inhibitors
A
- Enfuvirtide
- Miravoroc
2
Q
Examples of reverse transcriptase inhibitors
A
Nucleoside/tide inhibitors
Non-nucs
3
Q
Example of integrase inhibitor
A
Raltegravir
4
Q
Examples of protease inhibitors
A
- Lopinavir
- Ritonavir
- Atazanavir
5
Q
Describe GSK744
A
- An HIV integrase strand transder inhibitor
- analogue to DTG
6
Q
Advantage of GSK744 nanosuspensions
A
- allows 100% drug loading
7
Q
Components of GSK744 nanosuspension
A
- GSK744
- mannitol (tonicity agent)
- surfactant system (stabilizer)
- water for injection (solvent)
8
Q
Rationale for one regimen for all
A
- simplicity
- harmonizes regimens
- simplifies drug procurement
- safety in pregnancy
- efficacy against HBV
- EFV preferred NNRTI for people with HIV/TB
- affordability
9
Q
First line regimen
A
TDF
3TC/FTC
EFV
10
Q
Common side effects of HIV meds
A
- lipoatrophy
- lipodystrophy
- hepatotoxicity
- neuropathy
- rashed
- N+V
- anaemia
11
Q
Rationale for testing VL
A
- earlier capture of treatment failure
- help discriminate between failure and non-adherence
- lack of VL or CD4 capacity should not prevent starting ART
- same for adults and children
