Host Genetics Flashcards

1
Q

2 intracellular restriction factors

A
  • TRIM5a

- APOBEC3G

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2
Q

Role of TRIM5a

A

Prevents viral uncoating

  • in cytoplasmic bodies
  • binds to incoming particle
  • recruits to proteasome for degradation
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3
Q

Role of APOBEC3G

A

Cellular cytidine deaminase

  • changes cytidines to uridines
  • introduces mutations into HIV’s RNA
  • causes non-infectious viruses
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4
Q

What counteracts APOBEC3G?

A

Vif

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5
Q

Describe CCR5d32

A

32 base pair deletion in the CCR5 receptor gene

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