Host Genetics Flashcards
1
Q
2 intracellular restriction factors
A
- TRIM5a
- APOBEC3G
2
Q
Role of TRIM5a
A
Prevents viral uncoating
- in cytoplasmic bodies
- binds to incoming particle
- recruits to proteasome for degradation
3
Q
Role of APOBEC3G
A
Cellular cytidine deaminase
- changes cytidines to uridines
- introduces mutations into HIV’s RNA
- causes non-infectious viruses
4
Q
What counteracts APOBEC3G?
A
Vif
5
Q
Describe CCR5d32
A
32 base pair deletion in the CCR5 receptor gene