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IHO week 3 > T Cell receptors and MHC Complex-Diebel > Flashcards

T Cell receptors and MHC Complex-Diebel Flashcards

1
Q

CD-28 from T cell binds with ?

A

B7 (CD80-86) on APC

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2
Q

Th1’s are polarized by?

A

IL-12, IL-18, IFN-gama

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3
Q

Cytokines produced by Th1’s:

A

IFN-gama (most important), TNF

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4
Q

INF-gama does what?

A

induces ANGRY macrophages

induces more Th1s

pro-inflammatory agent

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5
Q

Angry macrophages produce which cytokines?

A

TNF-a

IL-1

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6
Q

Th17 polarized by ?

A

TGF-beta, IL-1, IL-6, and IL-23

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7
Q

Cytokines produced by Th17’s ?

A

IL-17, IL-22

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8
Q

Main job of Th17 ?

A

Inflammation

integrity of mucosal surfaces

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9
Q

Th2’s polarized by ?

A

IL-4

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10
Q

Cytokines produced by Th2’s ?

What do they do?

A

IL-4

IL-5

IL-13

Activate M2 Macs—-healing and debris removal

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11
Q

What other type of leukocyte is IL-4 a chemotactic factor for?

A

eosinophils

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12
Q

Tfh’s are polarized by?

A

IL-6

IL-21

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13
Q

Cytokines produced by Thf’s and what do they do?

A

IL-4, IL-21

cells migrate to lymph node follicles and encourage differentiation of B-cells depending on where they are located and which Ig’s are needed

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14
Q

Treg’s are polarized by?

A

IL-2, TGF-beta

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15
Q

Treg’s produce which cytokines and what do they do?

A

IL-10, TGF-beta

turn off other Th’s

1 Treg can suppress 1,000 other Th cells

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16
Q

Transcriptional regulator T-bet –> ?

A

Th1

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17
Q

Transcriptional regulator GATA3 –> ?

A

Th2

18
Q

Transcriptional regulator RORgamat –> ?

A

Th17

19
Q

Transcriptional regulator Bcl-6 –> ?

A

Tfh

20
Q

Transcriptional regulator FOXP3 –> ?

A

Treg

21
Q

What are the players in the “kiss of death” from CD8’s?

A

Fas (CD95) on infected cell and FAS ligand (CD95L) on CD8 —> leads to apoptosis of target cell

**CTL’s also kill by release of lytic granules (perlorins and granzymes)

22
Q

CTL’s (CD8+) are activated where and how?

A

Lymph nodes

contact with antigen-bearing DC’s and help from Th1’s via IL-2 and INF-gama

23
Q

What does “antigen specific and MHC-restricted” mean?

A

T-cell only recognized genetically identical (self) MHC’s

24
Q

What is meant by “cross presentation” on dendritic cells?

A

Some phagocytized antigen is allowed to leak into the intrinsic pathway and be presented on MHC 1 as well as the normal MHC 2 presentation at the same time

25
Q

What needs to happen for Macrophages to express MHC II?

A

Must be activated by phagocytosis

**Dendrites constituitively express high levels of MHC II.

**B-cells also constitutively express MHC II

26
Q

TCR is structurally reminiscent of ?

A

Fab region of an antibody

have 1 C and 1 V region, alpha/beta or gama/delta for both domains

27
Q

Genetic make up of TCRs?

Where does this happen?

A

receptors are made out of V, D, and J regions of both T-cell genes

Happens in the thymus

28
Q

That actual signal that turns a T cell on is transmitted through?

A

CD3

29
Q

Co-factors in the TCR-MHC interaction:

A

T-cell APC

CD28 ——— B7 (CD80/86)

LFA-1 ————- ICAM-1

CD2 —————- LFA-3

30
Q

V, J encodes for which chain of the TCR?

A

alpha chain

31
Q

V, D, J encodes for which chain of the TCR?

A

Beta chain

32
Q

Somatic mutations are present in TCR gene rearrangement, what enzymes are involved?

A

TdT adding up to 6 nucleotides at junctions between V-D-J junctions

***NO hypermutation in TCRs

once they leave the thymus they are locked in

33
Q

More diversity in MHC I’s or II’s?

**review the PPT (DP, DQ, DR)

A

II’s

I’s have a constant Beta chain

34
Q

HLA-B27 increases __________ risk by 90%.

A

ankylosing spondylitis

35
Q

HLA-DR2 linked to :

A

narcolepsy

MS

hay fever

SLE

36
Q

HLA-A3/B14 linked to :

A

hemochromatosis

37
Q

HLA-DQ2/GQ8 linked to :

A

Celiac disease

38
Q

HLA-DR3 linked to :

A

DM1, Grave’s Disease

39
Q

HLA-DR4 linked to :

A

RA, DM1

40
Q

HLA-B53 linked to :

A

protection against childhood malaria

41
Q

Each cell can produce how many different MHC I’s?

A

6

42
Q

Each cell can produce how many different MHC II’s?

A

12

IHO week 3 (11 decks)

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