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IHO week 3 > Antineoplastics > Flashcards

Antineoplastics Flashcards

1
Q

Naming convention: - TREX

A

folate analogues

METHOTREXATE (inhibits DHFR), PEMETREXED,
PRALATREXATE (inhibit thymidylate synthase)

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2
Q

Naming convention: CITABINE and ARABINE

A

Antimetabolites: inhibit DNA pol, and Ribonucleotide reductase (fludarabine)

CAPECITABINE, CLADARABINE,
CYTARABINE, FLUDARABINE,
GEMCITABINE

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3
Q

Naming convention: -PLATIN

A

platinum cross-linking agents

CISPLATIN, CARBOPLATIN,
OXALOPLATIN

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4
Q

Naming convention: -RUBICIN

A

Anthracycline antibiotics: intercalate DNA

DAUNORUBICIN, DOXORUBICIN,
EPIRUBICIN, IDARUBICIN

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5
Q

Naming convention: -MUSTINE

A

nitrosoureas: alkylating agents, cross link DNA

CARMUSTINE (BCNU), LOMUSTINE
CCNU

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6
Q

Naming convention: -TAXEL

A

taxanes: promote spindle growth

PACLITAXEL, CABAZITAXEL,
DOCATAXEL

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7
Q

Naming convention: -MYCIN

A

antibiotics: DNA strand breaks

BLEOMYCIN, MITOMYCIN

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8
Q

Naming convention: -TECAN

A

Camptothecins = topo I inhibitors, strand breaks

IRINOTECAN, TOPOTECAN

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9
Q

Naming convention: VIN…..INE

A

vinca alkyloids: inhibits spindle synthesis

VINBLASTINE, VINCRISTINE,
VINORELBINE

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10
Q
  • Prevent DNA synthesis
  • Block nucleotide synthesis (both purines and pyrimidines)
  • Inhibit dihydrofolate reductase
A

Methotrexate
Pemetrexed
Pralatrexate

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11
Q
  • Prevent DNA synthesis
  • Block purine synthesis
  • “Pseudofeedback inhibition” of PNP and PRPP
A

6-Mercaptopurine

6-Thioguanine

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12
Q
  • Prevent DNA synthesis
  • Block pyrimidine synthesis
  • Inhibit thymidylate synthase
A

Capecitabine
5-Fluorouracil
Pemetrexed
Pralatrexate

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13
Q

-Prevent DNA synthesis
-Block generation of deoxyribonucleotides
Inhibit ribonucleotide reductase

A

Cytarabine
Fludarabine
Gemcitabine
Hydroxyurea

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14
Q
  • Prevent DNA synthesis
  • Block DNA synthesis
  • Inhibit DNA polymerase
A

Cladarabine
Cytarabine
Fludarabine
Gemcitabine

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15
Q
  • Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
  • Crosslink DNA
  • Alkylating agents
A 
Busulfan
Carmustine (BCNU)
Chlorambucil
Cyclophosphamide
Dacarbazine
Ifosfamide
Lomustine (CCNU)
Mechlorethamine
Melphalan
Mitomycin
Procarbazine
Temozolamide
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16
Q
  • Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
  • Intercalate or form adducts with DNA
  • Anthracycline antibiotic (and related agents)
A 
Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
Mitoxantone
17
Q
  • Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
  • Cause DNA strand breaks
  • Free radical generation
A

Bleomycin

18
Q
  • Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
  • Cause DNA strand breaks
  • Form topoisomerase II-DNA complexes
A

Etoposide

19
Q
  • Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
  • Cause DNA strand breaks
  • Inhibit topoisomerase I
A

Irinotecan

Topotecan

20
Q
  • Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
  • Cause DNA strand breaks
  • Generate H2O2 (??)
A

Procarbazine

21
Q
  • Interrupt mitosis
  • Disrupt spindle formation
  • Terminate spindle assembly
A

Vinblastine
Vincristine
Vinorelbine

22
Q

Interrupt mitosis

  • Disrupt spindle formation
  • Enhance spindle formation
A

Paclitaxel

Ixabepilone

IHO week 3 (11 decks)

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