Antineoplastic Toxicities Flashcards
1
Q
Methotrexate:
A
Abortifacaent
2
Q
5-FU:
A
acute cerebellar syndrome
3
Q
6-MP
6-TG
A
tumor lysis syndrome (inc uric acid –> gout)
4
Q
Alkylating agents:
A
severe N/V
vesicant (blistering) if given IV
5
Q
Anthracyclines (Doxorubicin):
A
Cardiomyopathy (related to total lifetime dose)
red urine
*blue urine and sclera- Mitoxantone
6
Q
bleomycin:
A
pulmonary fibrosis
7
Q
etoposide:
A
hypotension, EKG changes
8
Q
Irinotecan:
A
diarrhea (treat with atropine or loperamide)
9
Q
Vincristine:
A
neurotoxicity (due to neurons reliance on microtubules in axonal transport)
*high lipophilicity–>fatal if given intrathecaly
10
Q
Paclitaxel:
A
peripheral neuropathy
hypersensitivity reactions
