PBL 1

Question 1

Describe initial interaction between measles and the immune system:

Answer 1

PAMP: ssRNA binds to TLR 7/8 →

activates NF-kB pathway

IFN-beta released first - trying to induce cells to express MHC-I → want to reveal you are harboring an infection

IFN-alpha, TNF-alpha (drive E selectin), IL-6, IL-12, IL-1 (fever) released

Question 2

the moral imperative to act for the benefit of others

Answer 2

benificence

Question 3

the directive against inflicting harm on others

Answer 3

nonmalificence

Question 4

recognizes the right of individuals to govern their own behavior

Answer 4

automnomy

Question 5

calls for the fair, equitable, and appropriate distribution of scarce goods

Answer 5

justice

Question 6

best societal outcome, even if at the expense of others

Answer 6

Utilitarianism

Question 7

Receptors involved in T-cells helping B-cells develop long term humoral immunity?

Answer 7

CD40 and CD40L