Acute Lymphoblastic Leukemia

Question 1

How is ALL classified?

Answer 1

By immunophenotype– B vs T

Question 2

More common patient population for ALL?

Answer 2

Children

Question 3

Why is TdT important in recognizing ALL?

Answer 3

only present in lymphoBLASTS

Question 4

T-cell surface Ags?

Answer 4

CD 3,4,8

Question 5

B-cell surface Ags?

Answer 5

CD 19,20,21

Question 6

Of the two immunophenotypes of ALL, which has worse prognosis?

Answer 6

T-lymphoblastic

Question 7

T-Lymphoblastic Leukemia is the same as:

Answer 7

T-Lymphoblastic Lymphoma

Question 8

• common in teenage male with mediastinal mass
• WBC usually very high
• bad prognosis

Answer 8

T-Lymphoblastic Leukemia

**mediastinal mass–thymus?

Question 9

What indicates a worse prognosis in B-Lymphoblastic Leukemia?

Answer 9

Ph+, (Philidelphia translocation)

Question 10

Age range with best prognosis in ALL:

Answer 10

1-10

Question 11

What chromosomal characteristic is associated with better prognosis in ALL?

Answer 11

hyperdiploidy (more chromosomes)

Question 12

With respect to WBC count, less than what level is associated with better prognosis?

Answer 12

50,000

Question 13

Tx for ALL:

Answer 13

Chemo +/- BM transplant

**many children are cured