T cell/NK cell, WBC III, Putthoff, lec Flashcards
Patient has lymphadenopathy, eosiniphilia and fever with weight loss
+ CD2 3 and 5
pleomorphic mixture malignant T cells
what is Dx and prognosis?
peripheral T cell lymphoma unspecifiec
worse prognosis than B cell analogues
rearrangements on chrom 2 p23 cause what
ALK fusion gene that activates tyrosine kinase for RAS JAK/STAT
blood smear shows horse shoe shaped nuclei with “hallmark Cells”
Dx
anaplastic large cell lymphoma
which cancer is ALK+? prognosis?
anaplastic large cell lymphoma
in children good prognosis
where does anaplastic large cell lymphoma invade
cluster venules and infiltrate lymphoid sinuses
anaplastic large cell lymphoma has what CD +
CD30 +
Which cancer is associated with patients infected with HTLV-1
acute T cell leukemia/lymphoma
where is HTLV-1 endemic
S japan, W africa and caribbean basin
Sx Adult T cell leukemia/lymphoma
skin lesions, generalized lymphadenopathy, HSM, lymphocytosis, hypercalcemia
clover leaf or flower cells are indicative of what
adult T cell leukemia/lymphoma
what is prognosis of adult T cell leukemia/lymphoma
rapidly prgressive
fatal in mo to eyars
What is sezary syndrome and when is it seen
exfoliative erythroderma with leukemia sezary cells that have cerebriform nuclei
mycosis fungoides
phases of mycosis fungoides
premycotic
plaque
tumor
what does mycosis fungoides express on surface
CLA, CCR4, CCR10
prognosis and complication with mycosis fungoides
8-9 yrs
can progresss to T cell lymphoma
what cancer is associated with cerebriform nuclei
sezary cells so mycosis fungoides
CD3- CD56+
NK variant of large granular lymphocytic leukemia
or!!
extranodal NK/T cell lymphoma
need to differentiate based on clincal presentation
what will you see on smear of large granular lymphocytic leukemia
large lymphocytes with blue cytoplasm and azurophilic granules
What are the main clinical features of large granular lymphocytic leukemia
neutropenia and anemia
What is felty syndrome and what is it assoc with
triad of RA, splenomegaly and neutropenia
sometimes seen in large granular lymphocytic leukemia
What gene is mutated in large granular lymphocytic leukemia
STAT3
What are CD markers for variants of large granular lymphocytic leukemia
T cell is CD3+
NK is CD3- and CD56+
which type of large granular lymphocytic leukemia is more aggressive
NK
Asian patient with EBV and destructive nasopharyngeal mass and azurophlic granules in blood
Dx? what will CD show
extranodal NK/T cell lymphoma
CD3- CD56+
Tx for extranodal NK/T cell lymphoma
aggressive
radiation not chemo
Hodgkins comes form what cell lineage
B cell, neplastic giant cells called reed sternberg
what is characteristic of RS cells and which variant does not have them
owl eyed nucleus
not seen in lymphocyte predominace, see L &H cells there
how are hodgkins lymphomas ranked
staging because spread in orderly fasion
What is population affected by hodgkins
age 32 avg Dx age
common cancer in young adults
what do RS do
release cytokines and factors that cross talk with other cells and increase # reactice lymphocytes, macrophages and granulocytes
What is most common type of hodgkins and characteristics
nodular sclerosis, desposition of collagen bands, lower cervical and supraclavicular adenopathy
not assoc with EBV
What are the markers for classical hodgkins
PAX5+ CD15+ CD30+
CD45-
EBV is associated with which types of hodgkins in order of most likley
lymphocyte depletion
mixed cellulartiy
lymphocyte rich
Which variants of hodgkins have systemic Sx
mixed cellularity, depletion and rich
What is the nonclassical hodgkins and why?
characteristics?
have B cell markers CD20+, BCL6+, CD15- CD30-
lymphocyte predominance
multilobated nucleus “popcorn cell”
L&H cells not RS
What age group is affected by the lymphocyte predominance hodgkins
males <35 with cervical or axillary adenopathy
which hodgkins has less favorable outcome
lymphocyte depletion
which hodgkins can transform to a tumor resembling DLBCL
lymphocyte predominance
What is used in Tx for hodgkins
anti CD30 Ab
overall general Sx of hodkgins
painless lymphadenopathy
