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Year 2 Heme lymph > T cell/NK cell, WBC III, Putthoff, lec > Flashcards

T cell/NK cell, WBC III, Putthoff, lec Flashcards

1
Q

Patient has lymphadenopathy, eosiniphilia and fever with weight loss
+ CD2 3 and 5
pleomorphic mixture malignant T cells
what is Dx and prognosis?

A

peripheral T cell lymphoma unspecifiec

worse prognosis than B cell analogues

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2
Q

rearrangements on chrom 2 p23 cause what

A

ALK fusion gene that activates tyrosine kinase for RAS JAK/STAT

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3
Q

blood smear shows horse shoe shaped nuclei with “hallmark Cells”
Dx

A

anaplastic large cell lymphoma

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4
Q

which cancer is ALK+? prognosis?

A

anaplastic large cell lymphoma

in children good prognosis

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5
Q

where does anaplastic large cell lymphoma invade

A

cluster venules and infiltrate lymphoid sinuses

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6
Q

anaplastic large cell lymphoma has what CD +

A

CD30 +

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7
Q

Which cancer is associated with patients infected with HTLV-1

A

acute T cell leukemia/lymphoma

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8
Q

where is HTLV-1 endemic

A

S japan, W africa and caribbean basin

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9
Q

Sx Adult T cell leukemia/lymphoma

A

skin lesions, generalized lymphadenopathy, HSM, lymphocytosis, hypercalcemia

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10
Q

clover leaf or flower cells are indicative of what

A

adult T cell leukemia/lymphoma

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11
Q

what is prognosis of adult T cell leukemia/lymphoma

A

rapidly prgressive

fatal in mo to eyars

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12
Q

What is sezary syndrome and when is it seen

A

exfoliative erythroderma with leukemia sezary cells that have cerebriform nuclei
mycosis fungoides

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13
Q

phases of mycosis fungoides

A

premycotic
plaque
tumor

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14
Q

what does mycosis fungoides express on surface

A

CLA, CCR4, CCR10

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15
Q

prognosis and complication with mycosis fungoides

A

8-9 yrs

can progresss to T cell lymphoma

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16
Q

what cancer is associated with cerebriform nuclei

A

sezary cells so mycosis fungoides

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17
Q

CD3- CD56+

A

NK variant of large granular lymphocytic leukemia
or!!
extranodal NK/T cell lymphoma
need to differentiate based on clincal presentation

18
Q

what will you see on smear of large granular lymphocytic leukemia

A

large lymphocytes with blue cytoplasm and azurophilic granules

19
Q

What are the main clinical features of large granular lymphocytic leukemia

A

neutropenia and anemia

20
Q

What is felty syndrome and what is it assoc with

A

triad of RA, splenomegaly and neutropenia

sometimes seen in large granular lymphocytic leukemia

21
Q

What gene is mutated in large granular lymphocytic leukemia

A

STAT3

22
Q

What are CD markers for variants of large granular lymphocytic leukemia

A

T cell is CD3+

NK is CD3- and CD56+

23
Q

which type of large granular lymphocytic leukemia is more aggressive

A

NK

24
Q

Asian patient with EBV and destructive nasopharyngeal mass and azurophlic granules in blood
Dx? what will CD show

A

extranodal NK/T cell lymphoma

CD3- CD56+

25
Q

Tx for extranodal NK/T cell lymphoma

A

aggressive

radiation not chemo

26
Q

Hodgkins comes form what cell lineage

A

B cell, neplastic giant cells called reed sternberg

27
Q

what is characteristic of RS cells and which variant does not have them

A

owl eyed nucleus

not seen in lymphocyte predominace, see L &H cells there

28
Q

how are hodgkins lymphomas ranked

A

staging because spread in orderly fasion

29
Q

What is population affected by hodgkins

A

age 32 avg Dx age

common cancer in young adults

30
Q

what do RS do

A

release cytokines and factors that cross talk with other cells and increase # reactice lymphocytes, macrophages and granulocytes

31
Q

What is most common type of hodgkins and characteristics

A

nodular sclerosis, desposition of collagen bands, lower cervical and supraclavicular adenopathy
not assoc with EBV

32
Q

What are the markers for classical hodgkins

A

PAX5+ CD15+ CD30+

CD45-

33
Q

EBV is associated with which types of hodgkins in order of most likley

A

lymphocyte depletion
mixed cellulartiy
lymphocyte rich

34
Q

Which variants of hodgkins have systemic Sx

A

mixed cellularity, depletion and rich

35
Q

What is the nonclassical hodgkins and why?

characteristics?

A

have B cell markers CD20+, BCL6+, CD15- CD30-
lymphocyte predominance
multilobated nucleus “popcorn cell”
L&H cells not RS

36
Q

What age group is affected by the lymphocyte predominance hodgkins

A

males <35 with cervical or axillary adenopathy

37
Q

which hodgkins has less favorable outcome

A

lymphocyte depletion

38
Q

which hodgkins can transform to a tumor resembling DLBCL

A

lymphocyte predominance

39
Q

What is used in Tx for hodgkins

A

anti CD30 Ab

40
Q

overall general Sx of hodkgins

A

painless lymphadenopathy

Year 2 Heme lymph (28 decks)

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