hematopoiesis CIS, putthoff Flashcards
granular lymphocytes
NK lymphoma
CML as leukemia is classified as what
myeloproliferative syndrome
where do platelets come from
myeloid cell lineage
early, significant life-threatening bleeding
acute promyelocytic leukemia M3 in AFB
translocation in APL
t15;17
CD56
NK
CD 3 and 5
B cell
CD45
all WBC
used to differentiate between lymphoreticular and carcinomas
CD11c
hairy cell leukemia
T cell markers
ALK, NOTCH1 mutations
BCL2, BCL6
diffuse large b cell lymphoma
CD30 CD34 CD11c
B cell markers
CD 30 can be + in anaplastic T cell lymphoma (ALK+)
C-MYC
Burkitt lymphoma
t14;18
C-myc
MYD 88
lymphoplasmacytic lymphoma
peroxidase and non-specific esterase activity is most likely discernible in AML (Mo) CML ALL CMML CLL
peroxidase stains granulocytes
non-specific esterase stains monocytic
CMML
CML stains peroxidase or non-specific esterase?
peroxidase
what can progress to DLBCL
CLL follicular lymphoma T cell immunodeficiency assoc with EBV marginal zone lymphoma lymphoplasmacytic lymphoma
42 y.o F with Dx infiltrating ductal carcinoma and all 14 nodes examined show exuberante histiocytosis with intracell pigment depositions consistent with? metastatic infiltrating ductal carcinoma reactive metachronous lymphoma histiocytosis X tingible body anthracosis
Reactive
histiocytes have macrophages and dendritic cells
5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is still most likley? acute pyogenic infection N meninginitis acute leukemia ALL CML
Acute b cell leukemia
5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is stiff
peripheral blas count is 15%
which if + is most useful in corroborating most likely Dx
terminal dinucleotide transferase
5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is stiff
peripheral blas count is 15%
which implies better prognosis
t 12;21
17 y.o M with high WBC and low platelet low Hct
peripheral blast is 25% and BM has 40% blast
recent fevers and weight loss
+ peroxidase and non-specific esterase
significant mucosal hemorrhage of gingica and circumoral areas
best Dx?
-myelodysplastic syndrome
-polycythemia vera
-AMML
-Acute T cell leukemia
CMML with blast crisis
AMML
45 y.o F with high WBC, left shift neutrophilia, eos and basophils platelet is lower of normal low grade fevers that coem and go no organomegaly history of SLE what would be useful in categorizing acute syndrome? -immunocytochemistry for peroxidase -LAP -non-specific esterase - BCL 10 t(9;22)
LAP
leukocyte alkaline phosphatase
high if reactive
low if myeloid
52 y.o M generalized lymphadenopathy and splenomegaly high WBC with lymphocytosis platelet count 157,000 (norm) spleen looks like follicular lymphoma most likely is? -T cell neoplasm -hairy cell leukemia -mature B cell neoplasm -sezary syndrome -diffuse large b cell lymphoma
mature B cell
52 y.o M generalized lymphadenopathy and splenomegaly high WBC with lymphocytosis platelet count 157,000 (norm) spleen looks like follicular lymphoma genetic analysis will most likely exhibit what BCL2 - c-MYC EBV + t 14;18 9;22
t14;18
17 y.o M irritable bowel syndrome for 6 mo and weight loss lesions in ileum biopsy from GI tract lesion shows starry sky following is most likely -BCL2 -EBV + -c-MYC -t14;18 -mucinous adenocarcinoma
c-MYC, burkitt
62 y.o F with unremarkable CBC waldeyers ring has mass and responds to anti CD20 molecular profiling indicates dyregulation BCL6 most consistent with? -hodgkins -richter syndrome -HTLV-1 -HHV8 -mature B cell neoplasm
a mature b cell neoplasm
diffuse large b cell lymphoma
57 y.o M with rigors fever and acute lobar pneumonia
lymphadenopathy and splenomegaly
nodules in small bowel
biospy looks like mantle cell lymphoma
lymphomatoid polyposis
CD5+, CD23-
