Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Year 2 Heme lymph > hematopoiesis CIS, putthoff > Flashcards

hematopoiesis CIS, putthoff Flashcards

1
Q

granular lymphocytes

A

NK lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CML as leukemia is classified as what

A

myeloproliferative syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

where do platelets come from

A

myeloid cell lineage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

early, significant life-threatening bleeding

A

acute promyelocytic leukemia M3 in AFB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

translocation in APL

A

t15;17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CD56

A

NK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CD 3 and 5

A

B cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CD45

A

all WBC

used to differentiate between lymphoreticular and carcinomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CD11c

A

hairy cell leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

T cell markers

A

ALK, NOTCH1 mutations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

BCL2, BCL6

A

diffuse large b cell lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CD30 CD34 CD11c

A

B cell markers

CD 30 can be + in anaplastic T cell lymphoma (ALK+)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

C-MYC

A

Burkitt lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

t14;18

A

C-myc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MYD 88

A

lymphoplasmacytic lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q 
peroxidase and non-specific esterase activity is most likely discernible in
AML (Mo)
CML
ALL
CMML
CLL
A

peroxidase stains granulocytes
non-specific esterase stains monocytic
CMML

17
Q

CML stains peroxidase or non-specific esterase?

A

peroxidase

18
Q

what can progress to DLBCL

A 
CLL
follicular lymphoma
T cell immunodeficiency assoc with EBV
marginal zone lymphoma
lymphoplasmacytic lymphoma
19
Q 
42 y.o F with Dx infiltrating ductal carcinoma and all 14 nodes examined show exuberante histiocytosis with intracell pigment depositions
consistent with?
metastatic infiltrating ductal carcinoma
reactive
metachronous lymphoma
histiocytosis X
tingible body anthracosis
A

Reactive

histiocytes have macrophages and dendritic cells

20
Q 
5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is still
most likley?
acute pyogenic infection
N meninginitis
acute leukemia
ALL
CML
A

Acute b cell leukemia

21
Q

5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is stiff
peripheral blas count is 15%
which if + is most useful in corroborating most likely Dx

A

terminal dinucleotide transferase

22
Q

5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is stiff
peripheral blas count is 15%
which implies better prognosis

A

t 12;21

23
Q

17 y.o M with high WBC and low platelet low Hct
peripheral blast is 25% and BM has 40% blast
recent fevers and weight loss
+ peroxidase and non-specific esterase
significant mucosal hemorrhage of gingica and circumoral areas
best Dx?
-myelodysplastic syndrome
-polycythemia vera
-AMML
-Acute T cell leukemia
CMML with blast crisis

A

AMML

24
Q 
45 y.o F with high WBC, left shift neutrophilia, eos and basophils
platelet is lower of normal
low grade fevers that coem and go
no organomegaly
history of SLE
what would be useful in categorizing acute syndrome?
-immunocytochemistry for peroxidase
-LAP
-non-specific esterase
- BCL 10
t(9;22)
A

LAP
leukocyte alkaline phosphatase
high if reactive
low if myeloid

25
Q 
52 y.o M generalized lymphadenopathy and splenomegaly
high WBC with lymphocytosis
platelet count 157,000 (norm)
spleen looks like follicular lymphoma
most likely is?
-T cell neoplasm
-hairy cell leukemia
-mature B cell neoplasm
-sezary syndrome
-diffuse large b cell lymphoma
A

mature B cell

26
Q 
52 y.o M generalized lymphadenopathy and splenomegaly
high WBC with lymphocytosis
platelet count 157,000 (norm)
spleen looks like follicular lymphoma
genetic analysis will most likely exhibit what
BCL2 -
c-MYC
EBV +
t 14;18
9;22
A

t14;18

27
Q 
17 y.o M irritable bowel syndrome for 6 mo and weight loss
lesions in ileum
biopsy from GI tract lesion shows starry sky
following is most likely
-BCL2
-EBV +
-c-MYC
-t14;18
-mucinous adenocarcinoma
A

c-MYC, burkitt

28
Q 
62 y.o F with unremarkable CBC
waldeyers ring has mass and responds to anti CD20
molecular profiling indicates dyregulation BCL6
most consistent with?
-hodgkins
-richter syndrome
-HTLV-1
-HHV8
-mature B cell neoplasm
A

a mature b cell neoplasm

diffuse large b cell lymphoma

29
Q

57 y.o M with rigors fever and acute lobar pneumonia
lymphadenopathy and splenomegaly
nodules in small bowel
biospy looks like mantle cell lymphoma

A

lymphomatoid polyposis

CD5+, CD23-

Year 2 Heme lymph (28 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions