Intro WBC I, Putthoff, lec Flashcards
What mediators help convert common myeloid to the RBC/platelet/basophil precursor
thrombopoietin, IL-11
IL5 transforms common myeloid progenitor into what
eosinophil
GM-CSF transforms common myeloid progenitor into what
neutrophil and monocyte
what are the factors that work on a stem cell
SCF, IL6 and Flt3L
where is the main site blood formation shortly until birth
in the liver
where is hematopoeitcally active tissue in adult
BM of axial skel
What are the 3 basic types of peripheral blood WBC
granulocytes, monocytes and lymphocytes
what are granulocyates
eos, neutrophils and basophils
when need more platelets how much can body increase production by
10 fold
life span of circulatin platelets
7-10 days
where do platelets come from
fragments of megakaryocytes
what are the RBC precursor cells
proerythroblast basophilic erythroblast polychromatophilic erythroblast normoblast nucleated red cell
what regulates RBC production
EPO
where is EPO made
peritubular capillary lining cells of kidney and some in liver
how is EPO secretion regulate
pO2
how long does it take to produce RBC from origin in marrow to peripheral blood
4 days
what is a reticulocyte
immature RBC, larger
how long do reticulocytes circulate
2-3 days before remnants of ER extruded
when are RBC removed form circulation
~120 days
where are RBC removed
red pulp of spleen bye specific macrophages
when a monocyte exits intravascular space and into tissue what occurs
becomes macrophage
what are the precursor cells for granulocytes
myeloblast, promeylocyte, myelocyte, metamyelocyte, juvenile granulocyte
what is the earliest form of granulocyte that can be seen in peripheral blood normally
metamyelocyte
what does an immature neutrophil look like
band, horseshoe nucleus
