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Year 2 Heme lymph > CIS, cumulative Part I > Flashcards

CIS, cumulative Part I Flashcards

1
Q

most common type anemia encountered clinically

A

diminished/decreased red cell production

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2
Q 
4 y.o M with fever and dry cough
petechial hemorrhages on chest and around eyes
suspect thrombocytopenia and order CBC
most likely Dx?
-Bernard Soulier
-ALL-B
-DLBCL
-Hereditary spheorocytosis
-Acute ITP
A

dDx
ALL-B
Acute ITP

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3
Q 
4 y.o M with fever and dry cough
petechial hemorrhages on chest and around eyes
suspect thrombocytopenia and order CBC shows lymphocytosis low platelets and mild splenomegaly
most likely Dx?
-Bernard Soulier
-ALL-B
-DLBCL
-Hereditary spheorocytosis
-Acute ITP
A

ALL-B

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4
Q

What is indicated for ALL-B

  • platelet adhesion study
  • serum ferritin
  • Hb electrophoresis
  • osmotic fragility testing- red cells
  • Haptoglobin
  • karyotyping
  • bone marrow aspirate and biopsy
  • flow cytometry
  • myeloperoxidase study
  • white cell differential
A 
white cell differential
karyotyping
bone marrow aspirate and biopsy
flow cytometry
myeloperoxidase
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5
Q

myeloperoxidase study in peripheral blood is looking for what

A

AML

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6
Q

what are examples of flow cytometry

A

tdt, CD markers etc

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7
Q 
45 y.o M dysphagia, focally cystic mass in L neck
7.5 cm mass extending midline of upper thorax
reasonable on ddx?
-thyroid carcinoma
-thymoma
-DLBCL
-hodgkin lymphoma
-germ cell tumor
A

All of those

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8
Q

45 y.o M dysphagia, focally cystic mass in L neck
7.5 cm mass extending midline of upper thorax
biopsies show unremarkable thymic cortical and medullary regions
best dx?
-thymoma
-malignant thymoma
-squamous cell carcinoma
-graves
-germ cell tumor

A

thymoma

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9
Q

thymoma has been associated with

  • cushing
  • myasthenia gravis
  • pure red cell aplasia
  • graves
  • pernicious anemia
A

myasthenia gravis

all of them really

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10
Q 
22 y.o M in MVA, 15 min later heli
massive gliding abrasions down to bone
near total amputation of distal third of R leg, semi conscious, tachy, pale low BP
intubated and urinary bladder inserted no output observed
CBC included
most likley:
-slightly dec Hct
-increased MCV
-Increased RDW
-Leukocytosis
-Reticulocytosis
A

slightly dec Hct

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11
Q 
14 y.o female with low grade fever, anemia and splenomegaly juandice
most likely
-chronic blood loss
-sickle cell disease
-beta thalassemia
-hereditoary spherocytosis
-parvovirusB19
A

hereditary spherocytosis

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12
Q 
14 y.o female with low grade fever, anemia and splenomegaly juandice
absolute lymphocytosis
suffer aplastic crisis
transfused, weks later has colicky abdominal pain
splenectomy and cholecytectomy
caliculi from GB are most likley
-calcium oxalate
-triple ammonium phosphate
-bilirubin/heme metabolites
-uric acid
-aggregates of Salmonella sp
A

bilirubin/heme

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13
Q

struvite stones, triple ammonium phosphate assoc with

A

infections

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14
Q

splenectomy more increased risk for infection with what

A

encapsulated bacteria

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15
Q

11 y.o F sore throat and fever, purulent cough
improves with antibiotics but 3 days later tired and listless
peripheral smear shows bite cell with heinz bodies
most likely Dx?
assoc with?

A

G6PD

oxidant stress

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16
Q

52 y.o M with low Hb RDW 19% high platelet
constipation abdominal pain, weakness, malaise
general pallor with pale conjunctiva
best characterized as?

A

chronic blood loss anemia

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17
Q

52 y.o M with low Hb RDW 19% high platelet
constipation abdominal pain, weakness, malaise
general pallor with pale conjunctiva
small liver peptide has significant role in terms iron absorption in this disorder
what is the peptide
-haptoglobin
-hepcidin
-ferritin
-transferrin
-intrinsic factor

A

hepcidin

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18
Q 
52 y.o M with low Hb RDW 19% high platelet
constipation abdominal pain, weakness, malaise
general pallor with pale conjunctiva
most likely?
-low serum ferritin
-high transferrin saturation
-low TIBC
depleted hepcidin levels
-hemochromatosis
A

low serum ferritin

19
Q 
52 y.o M with low Hb RDW 19% high platelet
constipation abdominal pain, weakness, malaise
general pallor with pale conjunctiva
which etiology is most likely
-manopause
-aplastic anemia
-plasma cell dyscrasia
-adenocarcinoma of colon
-squamous cell carcinoma of lung
A

adenocarcinoma of colon

20
Q

42 y.o japanese F
mother had RA. she has low fever with painful swollen joints especially at articulations
RF+ and erosive arthritis
several lung lesions with granulomatous inflammation
normocytic normochromic anemia
most likely?
-early iron deficiency anemia
-anemia of chronic disease
-hemolytic anemia precipitated by seropositive spondyloarthropathy
-superimposition of myelodysplastic syndrome
-chronic blood loss anemia

A

anemia of chronic disease

21
Q

myelodysplasias are characterized by what generally

A

cytopenias

22
Q 
RA anemia of chronic disease
most likely?
- dec haptoglobin lebels
-dec hepcidin levels
-increased TIBC
-high serum ferritin level
-high serum iron/low storage iron (marrow)
A

high serum ferritin

23
Q 
RA anemia of chronic disease
most likely pathogenesis?
decreased hepcidin
inflammatory mediator IL6
increase CRP
hight EPO level
high TIBC
A

inflammatory mediator IL6

24
Q 
42 y.o japanese F
mother had RA. she has low fever with painful swollen joints especially at articulations
RF+ and erosive arthritis
several lung lesions with granulomatous inflammation
what explains lung?
-concomitant TB
-sarcoidosis
-syphilis
-RA
-bronchopulmonary aspergillosis
-MAI in an immunocompromised patient
A

RA

25
Q 
22 y.o M with pancytopenia
jaundiced and splenomegaly
increased liver transaminases
bone marrow aspirate shows hypercellularity and megakaryocytic hyperplasia
what is most likely?
-myeloproliferative syndrome
-aplastic anemia
-acute leukemia
-acute lymphoma
-beta thalassemia
A

myeloproliferative syndrome

26
Q

What is needed to Dx AML

A

20% blasts in aspirate

27
Q

44 y.o M with significatn normocytic normochromic anemia
PMH notable for radiation therapy for papillary carcinoma of the thyroid 10 yrs ago
had bone marrow transplant
PS shows leukoerythroblastosis
bone and whole body CT fails to reveal any mass lesions
most likely assoc with
-myeloproliferative syndrome
-chronic renal failure
-chronic liver failure
-metastatic papillary carcinoma; thyroid
-erythroblastic leukemia

A

myeloproliferative syndrome

28
Q

17 y.o M chronic posterior HA L CVA tenderness
microscopic hematuria
large mass L kidney and cystic mass in posterior fossa
retinal lesion R eye
RCmass is increased MCV increase
most likekly

A

VhL syndrome

EPO causing erythroblastosis

29
Q 
52 y.o M with low Hb norm MCV and RDW 19 (elevated)
high platelet
constipation, abdominal pain, weakness malaise
pallor pale conjunctiva
due to?
-celiac
-chronic blood loss anemia
- increased destruction red cells
-due to marrow replacement
-chronic inflammation
A

chronic blood loss

30
Q 
52 y.o M with low Hb norm MCV and RDW 19 (elevated)
high platelet
constipation, abdominal pain, weakness malaise
pallor pale conjunctiva
following etiologies is most likely?
-ET
-burkitt lymphoma
-marginal zone
carcinoma of colon
-yersinia enterocolitica infection
A

-carcinoma of colon

31
Q 
52 y.o M with low Hb norm MCV and RDW 19 (elevated)
high platelet
constipation, abdominal pain, weakness malaise
pallor pale conjunctiva
most likely?
-serum ferritin 10 (low)
-high transferrin saturation
-low TIBC
- depleted hepcidin
-hemochromatosis
A

low serum ferritin

32
Q

47 y.o hispanic with malaise and weakness
muscle spasms of UE and cog wheel rigidity
been on omeprazole since teenager for GERD
suffers bouts of gastritis
tone is glazed and beefy with multifocal leukoplakia
MCV 110 and PS hypersegmented PMNs
increase homocystein and methymalonate
most likely?
-infestation with diphyllobothrium latum
pernicious anemia
-folate deficiency
-primary thymidine deficiency
-polymyositis

A

-pernicious anemia

33
Q

Tx pernicious anemia?

A

parenteral B12

34
Q 
22 y.o F with microcytic hypochromic anemia
PS shows target cells and nucleated red cells
basophilic stippling in RBC
serum ferrritin increased
HbA2 increased
small quantitiy of HbF
most likely?
- Fe deficiency
-Beta thalassemia minor
-alpha thalassemia trait
-HbH disease
-PNH
A

beta thalassemia minor

35
Q 
27 y.o SLEwith weakness and SOB
Hct 12% RDW 25
PS fragmented forms
mild spenomegaly
direct coombs antiglobulin test + IgG
best characterized as immunohemolytic anemia of what type
-warm Ab
-cold agglutinin
-cold hemolysin
-cryoglobulin
-mycoplasmal
A

warm Ab

36
Q

38 y.o M sharp intermittent left chest pain and SOB
dry cough, episodic low grade temp
EKG unremarkable but elevated CRP and LDL
mild lymphocytosis
5 cm lytic lesion in lateral portion L 7th rib
most likely in terms of rib lesion?
-solitary plasmacytoma
-histiocytosis X
-MGUS
-metastatic prostate carcinoma
-lymphoplasmacytic lymphoma

A

solitary plasmacytoma

37
Q

38 y.o M sharp intermittent left chest pain and SOB
dry cough, episodic low grade temp
EKG unremarkable but elevated CRP and LDL
mild lymphocytosis
5 cm lytic lesion in lateral portion L 7th rib
biopsy rib shows macrophages and eos
scatter neutrophils binucleated plasma cell aggregates and mature lymphocytes identified
-histiocytosis X
-hodgkin lymohoma
-myeloproliferative syndrome
-solitary plasmacytoma
-granulocytic sarcoma

A

solitary plasmacytoma

38
Q 
24 y.o M complains chronic cough and GERD
urine is tea colored PE shows pitting edema lower legs
BUN cr elevated
platelet count low
platelet infusions prior to kidney biopsy
glomerular features consistent with FSGS
most likely?
-parvovirus B19
-HUS
-vWb disease
-HIV
-Chronic ITP
A

HIV

39
Q

72 y.o M with fatigue and weakness. 15 Lb loss in recent weeks
diffuse painless lymphadenopathy and HSM mildly jaundice
Hct 32% and RDW 19
BM aspirate shows plasma cell proliferation in paratrabecular distribution
Molecular profiling of BM shows mutations in MYD88 and flow cytometry CD19 20 +
Peripheral studies on blood are consistent with cold agglutinin Ab
most likely?
-multiple myeloma
-mycoplasma infection syndrome
-parvovirus B19
-lymphoplasmacytic lymphoma
-immunohemolytic anemia, NOS

A

lymphoplasmacytic lymphoma

40
Q

47 y.o M obese and indicates his service is to entertain VIPs
drinks alot
dull L upper quadrant pain for some time and episodically bleeding hemorrhoids
CBC unremarkable
imaging shows splenomegaly
mild pitting edema ankles
most likely cause of organomegaly?

A

congestive

41
Q 
57 y.o M weakness and lethargy
n/n anemia with significant splenomegaly t 9;22 most likley
-CMML
-anemia of chronic disease
-primary myelofibrosis
-richter syndrome
-CML
A

CML

42
Q 
67 y.o M with fatigue/ethargy and L foot pain
night sweaths and weight loss. n/n anemia with increased RDW
splenomegaly L shift WBC with eos/basophils
blast count 8% with hgih platelets
BM has 12% blasts and BCR ABL fusion
big toe swollen and painful at joint
most likley?
-myelodysplastic syndrome
-myeloproliferative syndrome
-CML in lymphoid blast crisis
-hairy cell leukemia
-AML
A

myeloproliferative syndrome

43
Q 
54 y.o F with fatigue lethargy night sweats and weight loss
n/n aemia with increased RDW
HSM liver shows EMH
left shift low WBC count
no blasts in PS
high platelet
7% blasts in BM with alrge dysplastic megakaryocytes in clusters
osteosclerosis
BM reticulin increased
pancytopenia develops and PS shows nucleated RBC with dacryocytic configurations
numerous acute infections from pyogenic bacteria and fungi
bleeding episodes
-CML
-APL
-TTP
-PV
-PM
A

Primary Myelofibrosis

44
Q

37 y.o G7P5 F has history HUS successfully Tx with supportive care
borderline kidney function with microcytic hypochroimc anemia
splenectomy 6 mo ago with rise in paltelet count
while getting platelet infusion, became hypotensive and SOB
cardiac arrest and was DOA at hostpial
most likely?
-immunohemolytic crisis
-primary cardiac disease
-DIC
-transfusion related complication
-fatal allergic reaction

A

transfusion related complication

Year 2 Heme lymph (28 decks)

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