Linger, final CIS antineoplastic agents

Question 1

cyclophosphamide and ifosfamide urologic toxic metabolite responsible for hemorrhagic cystitis

Answer 1

acrolein

Question 2

what rescues radiation induced xerostomia

Answer 2

amifostine

Question 3

what is used for MTX rescue

Answer 3

tetrahydrogolic acid (leucovorin)

Question 4

main reason for giving allopurinol prophylactically prior to starting course of chemo

Answer 4

reduce risk of hyperuricemia

Question 5

which drug, with use of allopurinol, should be used with extra caution

Answer 5

mercaptopurine

Question 6

34 HIV M with 6 mo Hx CD20+ DLBCL
chemo combination
current CD4 is 150 cells
which agent contraindicated

Answer 6

vinblastine

Question 7

administration of what drug combo is best for eliminating HS reactions assoc with paclitaxel,
pretreat with what?

Answer 7

diphenhydramine and Dexamethasone

Question 8

Chromosomal studies show t9:22

which most likely used in Tx?

Answer 8

imatinib

Question 9

Tx for large soft tissue sarcoma resected from retroperitoneum recieving radiation and chemo
mesna and another drug is used
what is other drugs MOA?

Answer 9

alkylation of DNA

Question 10

mesna is used to rescue actions of what

Answer 10

cyclophosphamide

Question 11

MOA for drug of choice for HER2/neu breast carcinoma

Answer 11

inhibition Pi of R Tyrosine Kinase

trastuzumab

Question 12

63 y.o female with metastatic colon cancer
overexpression EGFR
which agent most appropriate?

Answer 12

cetuximab

Question 13

which agent is used to block interaction of VEGF

Answer 13

bevacizumab

Question 14

aLL on cytarabine, vincristine, prednisone, aspariginase, allopurinol
difficulty with proprioception and has numbness in hands and feet. eyelid lag and ataxia. confusion?
cause of mental status?

Answer 14

asparaginase and cytarabine

vincristine is causing PNS neuropathy