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Exam 5 > T cell neoplasms > Flashcards

T cell neoplasms Flashcards

1
Q

PTCL NOS

A

Peripheral T cell lymphoma not otherwise specified

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2
Q

Eosinophilia. Weight loss.

Diffuse paracortical effacement. Mature T cell. Loss of one or more T cell antigen

A

Peripheral T cell lymphoma not otherwise specified

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3
Q

ALK gene on 2p23.

A

Anaplastic large cell lymphoma

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4
Q

ALCL

A

anaplastic large cell lymphoma

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5
Q

ALK fusion protein acts as ____________

A

tyrosine kinase

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6
Q

Hallmark cells are large, ____________ cells with horseshoe or wreath shaped nuclei

A

anaplastic

Anaplastic large cell lymphoma

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7
Q 
T cell or null cell 
No B cell antigens
CD30
EMA
ALK
A

Anaplastic large cell lymphoma

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8
Q

Generally in kids. Good prognosis.

A

ALK positive

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9
Q

Generally in adults. Less favorable prognosis

A

ALK -

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10
Q

T cell counterpart of DLBCL, but worse diagnosis than DLBCL.
Heterogenous group of T cell lymphomas that do not meet criteria for a different entity.

A

Peripheral T cell lymphoma not otherwise specified

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11
Q

CD4 T cells infected with HTLV-1

A

Adult T cell leukemia/lymphoma

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12
Q

Endemic in caribbean basin, Japan, West Africa

A

HTLV-1

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13
Q

Much less aggressive if localized to skin alone

A

Adult T cell leukemia/lymphoma

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14
Q

Leukemic form is rapidly progressive, most die within one year despite chemo

A

Adult T cell leukemia/lymphoma

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15
Q

Has flower/cloverleaf cells

A

Adult T cell leukemia/lymphoma

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16
Q

MF and SS

A

Mycosis fungoides

Sezary syndrome

17
Q

Skin only

A

Mycosis Fungoides

18
Q

Progressed from skin to include leukemia

A

Sezary syndrome

19
Q

MF and SS usually affect

A

CD4 T cells

20
Q

Has 3 stages

patch > plaque > tumor

21
Q

Generalized exfoliative erythroderma has spread to include leukemia. Involves nodes and BM now

A

Sezary Syndrome

22
Q

Cerebriform nuclear contours

A

Neoplastic cell in skin for MF/SS

23
Q

Neoplastic cell in blood for MF/SS

A

Sezary cell

24
Q

Indolent if limited to less than 10% of body. When extensive, organ involvement occurs

25
Q

LGLL

A

Large granular lymphocytic leukemia

26
Q

Has T cell type and NK cell type

A

Large granular lymphocytic leukemia

27
Q

Neutropenia with decreased myeloid maturation in BM

Anemia associated

A

Large granular lymphocytic leukemia

28
Q

Underlying cause of Felty syndrome

A

Large granular lymphocytic leukemia

29
Q

Rh arthritis, splenomegaly, and neutropenia

30
Q

T cell LGLL is _____

NK cell LGLL is _______

A

indolent

aggressive

31
Q

Presents as lethal midline granuloma. Aggressive. Invade vessels leading to necrosis

A

Extranodal NK/T cell lymphoma

Exam 5 (8 decks)

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