T cell neoplasms Flashcards
PTCL NOS
Peripheral T cell lymphoma not otherwise specified
Eosinophilia. Weight loss.
Diffuse paracortical effacement. Mature T cell. Loss of one or more T cell antigen
Peripheral T cell lymphoma not otherwise specified
ALK gene on 2p23.
Anaplastic large cell lymphoma
ALCL
anaplastic large cell lymphoma
ALK fusion protein acts as ____________
tyrosine kinase
Hallmark cells are large, ____________ cells with horseshoe or wreath shaped nuclei
anaplastic
Anaplastic large cell lymphoma
T cell or null cell No B cell antigens CD30 EMA ALK
Anaplastic large cell lymphoma
Generally in kids. Good prognosis.
ALK positive
Generally in adults. Less favorable prognosis
ALK -
T cell counterpart of DLBCL, but worse diagnosis than DLBCL.
Heterogenous group of T cell lymphomas that do not meet criteria for a different entity.
Peripheral T cell lymphoma not otherwise specified
CD4 T cells infected with HTLV-1
Adult T cell leukemia/lymphoma
Endemic in caribbean basin, Japan, West Africa
HTLV-1
Much less aggressive if localized to skin alone
Adult T cell leukemia/lymphoma
Leukemic form is rapidly progressive, most die within one year despite chemo
Adult T cell leukemia/lymphoma
Has flower/cloverleaf cells
Adult T cell leukemia/lymphoma
MF and SS
Mycosis fungoides
Sezary syndrome
Skin only
Mycosis Fungoides
Progressed from skin to include leukemia
Sezary syndrome
MF and SS usually affect
CD4 T cells
Has 3 stages
patch > plaque > tumor
MF
Generalized exfoliative erythroderma has spread to include leukemia. Involves nodes and BM now
Sezary Syndrome
Cerebriform nuclear contours
Neoplastic cell in skin for MF/SS
Neoplastic cell in blood for MF/SS
Sezary cell
Indolent if limited to less than 10% of body. When extensive, organ involvement occurs
MF/SS
LGLL
Large granular lymphocytic leukemia
Has T cell type and NK cell type
Large granular lymphocytic leukemia
Neutropenia with decreased myeloid maturation in BM
Anemia associated
Large granular lymphocytic leukemia
Underlying cause of Felty syndrome
Large granular lymphocytic leukemia
Rh arthritis, splenomegaly, and neutropenia
LGLL
T cell LGLL is _____
NK cell LGLL is _______
indolent
aggressive
Presents as lethal midline granuloma. Aggressive. Invade vessels leading to necrosis
Extranodal NK/T cell lymphoma