Plasma neoplasms Flashcards
monoclonal protein identified in blood or urine
M protein
excess free monoclonal light chains that can damage renal tubules
bence jones proteinuria
________ have intracytoplasmic monoclonal light chain
plasma cell neoplasm
Include multiple myeloma, plasmacytoma, and monoclonal gammopathy of undetermined significance (MGUS)
plasma cell neoplasms
Have to have triad (M protein in blood or urine, end organ damage, and clonal plasma cells)
multiple myeloma
Monoclonal protein (IG) production. Inadequate normal IG production. Factors produced by neoplastic cells allow proliferation, survival, and cause BM destruction
multiple myeloma
Sxs include anemia, recurrent infections (decreased IGs), hypercalcemia, bone pain, renal insufficiency (BJ proteins), hyperviscosity (excess light chains), amyloidosis (light chain deposition in organs)
multiple myeloma
One class of IG elevated and other classes decreased
multiple myeloma
Causes bony lytic lesions, PB rouleaux (stacked coins)
multiple myeloma
Most common cause of monoclonal gammopathy. Progression to multiple myeloma can occur, but can’t predict who
monoclonal gammopathy of undetermined significance
MGUS
monoclonal gammopathy of undetermined significance
Must exclude all other causes of monoclonal gammopathy. Often same chromosomal aberrations as multiple myeloma. Periodic assessment of BJ and M proteins to check for progression to MM
MGUS
Solitary bone or soft tissue clonal plasma mass.
No marrow or organ disease.
Plasmacytoma
Most common bone site for plasmacytoma is ______
Most common soft tissue site is
spine
upper respiratory tract, oropharynx
Group of diseases. Clonal plasma cell differentiation secreting single IG
Plasma cell neoplasms
