Griswold

Question 1

AML

Answer 1

Acute Myeloid Leukemia

Question 2

CMPD

Answer 2

Chronic myeloproliferative disorders

Question 3

MDS

Answer 3

myelodisplastic syndromes

Question 4

Includes AML, CMPD, and MDS

Answer 4

Myeloid neoplasms

Question 5

CD34 and TdT

Answer 5

Immature lymphoblasts

Question 6

CD13, CD33, MPO

Answer 6

Myeloid

Question 7

CD19, CD20, kappa and lambda light chains

Answer 7

B cell

Question 8

CD3, CD4, CD8, CD5

Answer 8

T cell

Question 9

t(14;18)

Answer 9

Follicular lymphoma

Question 10

t(8;14)

Answer 10

Burkitt lymphoma

Question 11

t(11;14)

Answer 11

Mantle cell lymphoma

Question 12

t(15;17)

Answer 12

Acute promyelocytic leukemia

Question 13

t(9;22)

Answer 13

Chronic myeloid leukemia

Question 14

Caused from mistakes made during antigen receptor gene rearrangement. Mutations in precursor cells and mature B cells

Answer 14

Lymphoid neoplasms

Question 15

Caused by balanced translocations/inversions and acquired mutations in genes that regulate normal hematopoiesis

Answer 15

Myeloid neoplasms

Question 16

Genetic _______ has higher risk for acute leukemia

Answer 16

Fanconi syndrome

Question 17

Down syndrome (tri 21) and neurofibromatosis 1 has increased risk for

Answer 17

childhood leukemia

Question 18

Causes adult T cell leukemia/lymphoma (ATLL)

Answer 18

HTLV - 1

Question 19

Causes burkitt lymphoma, HL

Answer 19

EBV

Question 20

H pylori and hasimotos can cause

Answer 20

MALT lymphoma

Question 21

Lymph node enlargement

Answer 21

Lymphadenopathy

Question 22

Lymph node inflammation

Answer 22

Lymphadenitis

Question 23

Due to stimuli that activate B cells (humoral response). Tingable body macs in germinal center. Caused by toxoplasmosis, early HIV, most commonly by infections

Answer 23

follicular hyperplasia

Question 24

DDx of follicular hyperplasia

Answer 24

Follicular lymphoma

Question 25

Due to stimuli that activate T cells (cell mediated immunity). Commonly caused by viruses and chronic skin irritation.

Answer 25

Paracortical hyperplasia

Question 26

DDx for paracortical hyperplasia

Answer 26

T cell lymphoproliferative disorders

Question 27

Numerous macs within sinuses. Common in nodes draining cancer. Host response to malignant cells

Answer 27

Sinus histiocytosis

Question 28

Enlarged, red, tender soft nodes. Follicular hyperplasis. Drainage of infections. Common in kids

Answer 28

Acute nonspecific lymphadenitis

Question 29

Non tender node enlargement. Due to chronic immunological stimulation.

Answer 29

Chronic nonspecific lymphadenitis.

Question 30

Tissue involvement

Answer 30

Lymphoma

Question 31

BM/blood involvement

Answer 31

Leukemia

Question 32

2/3rd present with non-tender enlarged nodes. 1/3rd present extranodal

Answer 32

Lymphoma

Question 33

Involves BM so presents with signs of bone marrow failure. Can involve spleen and liver causing hepatosplenomegaly

Answer 33

Leukemia

Question 34

Anemia, infections, and bleeding are signs of ______

Answer 34

BM involvement

Question 35

Terminally differentiated B cells (plasma cells). Arise in BM.
Rarely involves nodes.
End stage leukemic.

Answer 35

Plasma cell neoplasms

Question 36

Fever, night sweats, weight loss

Answer 36

B symptoms

Question 37

Will recirculate periodically and are widespread on a molecular level at diagnosis

Answer 37

NHL

Question 38

Spreads in orderly fashion

Answer 38

HL

Question 39

Normal immune response is _________

Answer 39

polyclonal

Question 40

Neoplastic process is ________

Answer 40

monoclonal

Question 41

Include mutations in precursor cells, mature cells (NHL and HL)

Answer 41

Lymphoid neoplasms