HIV

Question 1

Enymatic complex including reverse transcriptase, DNA pol, RNAse, protease, and integrase

Answer 1

POL

Question 2

Corresponds to spikes on envelope

Answer 2

ENV

Question 3

Transcription transactivator for both viral and cellular control regions of genes.

Answer 3

TAT

Question 4

Regulates transport of viral mRNAs out of nucleus and into cytoplasm.
Regulates splicing of viral RNAs that lead to formation of mRNAs

Answer 4

REV

Question 5

Diminishes CD4 and MHC1 changing T cell signaling

Answer 5

NEF

Question 6

Required to achieve high viral load. Key component in turning limited HIV infection into full blown HIV replication

Answer 6

NEF

Question 7

Promotes virus assembly and blocks activation of APOBEC-36 apoptotic protein

Answer 7

VIF

Question 8

Enhances release of virus from infected cells and inhibits expression of CD4

Answer 8

VPU

Question 9

Arrests infected cells in G2 phase, optimal for HIV replication.
Enhances transport of proviral DNA (provirus) into nucleus

Answer 9

VPR

Question 10

Core and capsid structural proteins

Answer 10

GAG

Question 11

Detects HIV1 p-24 antigen

And antibodies to both HIV1 and HIV2

Answer 11

Rapid HIV test

Question 12

Antigens or antibodies permit earliest detection of HIV?

Answer 12

Antigens

Question 13

Antibodies to HIV appear _______ after acute infection

Majority of ppl develop antibodies (and have serum conversion) within _______ months

Answer 13

6days-1 month

3

Question 14

Absolute levels of _______ are of prognostic value

Answer 14

CD4 T cells

Question 15

Disease severity ________ as CD4 T cells decrease

Answer 15

increases

Question 16

Predictor of clinical outcome

Use along with CD4 T cell count to monitor effectiveness of antiviral therapy

Answer 16

Level of HIV1 RNA (viral load)

Question 17

Fourth generation test detects HIV ____________ in blood

Answer 17

p24 antigen