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Exam 5 > Lymphoid Neoplasms > Flashcards

Lymphoid Neoplasms Flashcards

1
Q

Neoplastic population of immature lymphocytes (blasts).

A

Lymphoblastic leukemia/lymphoma

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2
Q

Usually leukemia (BM and blood)

A

B-ALL

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3
Q

Usually lymphomic mediastinal mass

A

T-ALL

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4
Q

Most ALLs are of ___________ lineage

A

B cell

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5
Q

Most common cancer of children

A

Lymphoblastic leukemia/lymphoma

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6
Q

Incidence of pre-B ALL highest at age _____

A

4

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7
Q

Incidence of pre-T ALL highest ________

A

in adolescence

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8
Q

Abrupt stormy onset. Bone pain in kids. Hepatosplenomegaly.

A

Lymphoblastic leukemia/lymphoma

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9
Q

“hand mirror”

A

Lymphoblastic leukemia/lymphoma

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10
Q

TdT, CD19, CD10, CD79a, cCD3, surface light chain negative

A

Lymphoblastic leukemia/lymphoma

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11
Q

hyperdiploidy
t(9;22)
t(12;21)

A

Good prognosis PreB ALL

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12
Q

t(v;11q23)

MLL gene

A

Poor prognosis PreB ALL

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13
Q

Translocations involving TCR on chr 7 and 14

A

Pre T ALL

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14
Q

Complete remission 95% kids and 60-85% adults

A

ALLs

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15
Q

Less than 2, adolescent or adult presentation. High peripheral blast count. Unfavorable cytogenetics. Minimal residual disease after treatment. t(v;11q23)

A

Poor risk factors ALL

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16
Q

Ages 2-10. Low WBC count. Early Pre-B phenotype (CD19/CD10). Favorable cytogenetics.

A

Favorable prognostic factors

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17
Q

CLL/SLL

A

Chronic lymphotic leukemia/Small lymphocytic lymphoma

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18
Q

Leukemia. Leukocytosis and absolute lymphocytosis

A

chronic lymphocytic leukemia (CLL)

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19
Q

Lymphomatous

A

small lymphocytic leukemia SLL

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20
Q

Most common leukemia of adults in western world

A

chronic lymphocyctic leukemia

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21
Q

Mostly ppl older than 50. Most pts asymptomatic. WBC counts variable. Hepatosplenomegaly. Immune disruptions. Hypogammaglobulinemia, hemolytic anemia, thrombocytopenia

A

CLL/SLL

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22
Q

Small, mature lymphs with hyperclumped nuclear chromatin. Smudge cells

A

Chronic lymphocytic leukemia

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23
Q

CD19/CD5/CD23
dim CD20
dim surface light chain

A

Chronic lymphotic leukemia/Small lymphocytic lymphoma

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24
Q

Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to diffuse large b cell lymphoma

A

Richter syndrome

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25
Q

indolent

most pts die of other problems

A

CLL/SLL

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26
Q

Germinal center B cells that mimic normal lymphoid follicles. Second most common NHL. BM involvement.

A

Follicular lymphoma

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27
Q

Has 2 cell types (centocytes and centroblasts)

A

Follicular lymphoma

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28
Q

Small cleaved cells

A

centrocytes

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29
Q

Count for grading

A

Centroblasts

30
Q

Has paratrabecular BM aggregates

A

follicular lymphoma

31
Q

CD19, CD20, CD10
bright surface light chain
BCL2
BCL6

A

Follicular lymphoma

32
Q

In normal LN, only mantle zone B and T cells stain + for

33
Q

Not easily curable, but indolent.

A

Follicular lymphoma

34
Q

Normal architecture with follicles of varying size. Mantel zone polarization. Normal germinal centers w/ tingable body macrophages. Normal bcl2 staining in mantle zone

A

Follicular hyperplasia

35
Q

Architectural disruption with follicles of similar size. No mantle zone, no polarization. Abnormal follicle with no true germinal center. No tingable body macs. abnormal bcl2 staining

A

Follicular lymphoma

36
Q

Express CD5 and overexpress cyclin D1

A

Mantle cell lymphoma

37
Q

Hepatosplenomegaly. Mostly BM involvement. PB involvement varies. Has lymphomatoid polyposis or GI involvement

A

Mantle cell lymphoma

38
Q

MCL

A

mantle cell lymphoma

39
Q

CD19, CD20, CD5
bright CD20 and surface light chain

CD23 negative

A

mantle cell lymphoma

40
Q

t(11;14)

A

mantle cell lymphoma

41
Q

Aggressive. Most pts die of organ failure from tumor infiltration. Tx w/ rituximab (anti-CD20) and chemo combo.
BM transplant in younger pts
Majority ultimately relapse

42
Q

Tumor cell recapitulates normal MALT tissue. Often extranodal

A

Marginal zone lymphoma

43
Q

MZL

A

marginal zone lymphoma

44
Q

In tissues with chronic inflammation. May regress if inciting agent brought under control

A

marginal zone lymphoma

45
Q

Reactive polyclonal inflammatory rx.

polyclonal > oligoclonal > monoclonal

A

marginal zone lymphoma

46
Q

Resembless SLL but many neoplastic cells are plasma cells. Mainly BM involvement. Secretes monoclonal IgM causing hyperviscosity

A

Lymphoplasmacytic lymphoma

47
Q

LPL

A

lymphoplasmacytic lymphoma

48
Q

Secretes monoclonal IgM causing hyperviscosity syndrome known as

A

Waldenstrom macroglobulinemia

49
Q

IgM increases blood viscosity causing __________

A

visual and neurological sxs

Bleeding, autoimmune hemolytic anemia

50
Q

B cells involving blood, BM, and splenic red pulp. Present with sxs related to cytopenias. Splenomegaly, BM involvment

Diffuse fried eggs. Round, reniform nuclei with moderate amount cytoplasm. Cells incite reticulin fibrosis

A

Hairy cell leukemia

51
Q

HCL

A

hairy cell leukemia

52
Q

Infections, fatigue, weakness are ________ sxs

53
Q

Hairy B cell leukemia has PB involvement, but due to ______ can be hard to find cells

A

pancytopenia

54
Q

Neoplastic cells sensitive to purine analog type of chemo causing long remissions

A

hairy cell leukemia

55
Q

ALL

A

Lymphoblastic leukemia/lymphoma

56
Q

DLBCL

A

diffuse large B cell lymphoma

57
Q

High grade.

Mostly occurs in immunodeficient pts. Typically associated with EBV

58
Q

Rapidly enlarging, symptomatic mass nodal or extranodal. B symptoms. Large lymphocytes. Mitotically active.

59
Q

CD19, CD20
Surface light chain restriction

May or may not have BCL2, BCL6, or CD10

60
Q

cMYC mutation

61
Q

Aggressive and fatal if untreated.

62
Q

Highest grade of high grade

A

Burkitt lymphoma

63
Q

3 subtypes

  1. endemic EBV associated in Africa
  2. sporadic in US children
  3. Immunodeficient (HIV)
A

Burkitt lymphoma

64
Q

Translocation involving MYC

A

Burkitt lymphoma

65
Q

Usually extranodal only.

BM and PB involvement unusual

A

Burkitt lymphoma

66
Q

Usually associated with mandibular or orbital mass

A

EBV associated Burkitt lymphoma

67
Q

Usually associated with abdominal mass in ileocecum.

A

Sporadic in US children Burkitt lymphoma

68
Q

Rapid cell death and turnover. Death releases Ca, uric acid, and K. Medical emergency requiring hydration, binding agents for K and uric acid

Associated with?

A

Tumor lysis syndrome

Associated with burkitt lymphoma

69
Q

Diffuse infiltrate medium sized cells.
Cytoplasmic vacuoles
High mitotic activity (>99% proliferation)
Many macs creating “starry sky”

A

burkitt lymphoma

70
Q

CD19, CD20, CD10
surface light chain restriction
BCL6

A

Burkitt lymphoma

71
Q

t(8;14)

A

burkitt lymphoma

72
Q

Aggressive but responds well to intensive systemic chemo

A

burkitt lymphoma

Exam 5 (8 decks)

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