Hodgkins

Question 1

__________ includes nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted

Answer 1

Classical HL

Question 2

Most common type of HL

Second most common

Answer 2

Nodular sclerosis

Mixed cellularity

Question 3

Usually curable

Answer 3

HL

Question 4

Derived from germinal center or post germinal center B cells

Answer 4

Reed Sternberg cell

Question 5

Some Reed sternberg cells harbor ___________

Answer 5

EBV

Question 6

Bilobed to multi-lobed nucleus

Answer 6

classic RS cell

Question 7

single lobe nucleus

Answer 7

mononuclear RS cell

Question 8

Folded, multilobate nuclei. Cell sitting in hole.

Answer 8

Lacunar RS cell

Question 9

Like popcorn. Specific to NLPHL

Answer 9

L&H

Question 10

CD15/CD30

Negative for CD45, B, and T cell antigens

Answer 10

Classic RS cell

Question 11

B cell antigen
CD45/BCL6

Negative for CD15 and CD30

Answer 11

NLPHL RS cell

Question 12

Long term survivors of this have increased risk for 2nd malignancies due to alkylating chemo

Answer 12

HL

Question 13

Cervical, supraclavicular, and mediastinal adenopathy.
Lacunar cells. Polymorphous background.
RS cells vary in #

Answer 13

Nodular sclerosis

Question 14

EBV associated.
Older age, B symptoms.
Diffuse effacement by heterogenous infiltrate.
Classic RS cells

Answer 14

Mixed cellularity

Question 15

EBV associated in 40%.
Diffuse effacement
Many mononuclear and classic RS cells.
Lymphocytes make up background

Answer 15

Lymphocyte rich

Question 16

Numerous RS cells and few background cells.
DDx is DLBCL
Older pts, HIV +
EBV associated

Answer 16

Lymphocyte depleted

Question 17

Nodular effacement by small lymphs and some benign histiocytes.
L&H RS cells (popcorn). Can transform to DLBCL.
Cervical or axillary adenopathy

Answer 17

Nodular lymphocyte predominant (NLPHL)

Question 18

Two broad types of hodgkins includes

Answer 18

Classical

Nodular Lymphocyte Predominace (NLPHL)